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Found 21 Enz. Inhib. hit(s) with all data for entry = 50002026
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50452368(CHEMBL4215605)
Affinity DataKi:  0.75nMAssay Description:Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50452370(CHEMBL4209430)
Affinity DataKi:  0.840nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50452372(CHEMBL4204665)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to 5-HT1A receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50452371(CHEMBL4217339)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]8-OH-DPAT from rat cerebral cortex 5-HT1A receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50452366(CHEMBL4203932)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50118336(1-(5-Fluoro-benzo[b]thiophen-3-yl)-3-(4-quinolin-8...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]8-OH-DPAT from rat frontal cortex 5-HT1A receptor measured after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50452366(CHEMBL4203932)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50452368(CHEMBL4215605)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50118336(1-(5-Fluoro-benzo[b]thiophen-3-yl)-3-(4-quinolin-8...)
Affinity DataKi:  7.5nMAssay Description:Displacement of [3H]-paroxetine from rat cortical membranes measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataKi:  9.5nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50452370(CHEMBL4209430)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting metho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50452371(CHEMBL4217339)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-paroxetine from rat cerebral cortex SERTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of SERT in rat brain synaptosomes assessed as reduction in [3H]-5-HT uptake measured after 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50452370(CHEMBL4209430)
Affinity DataIC50:  100nMAssay Description:Inhibition of SERT in rat brain synaptosomes assessed as reduction in [3H]-5-HT uptake measured after 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50452372(CHEMBL4204665)
Affinity DataIC50:  195nMAssay Description:Binding affinity to SERT (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50452366(CHEMBL4203932)
Affinity DataIC50:  340nMAssay Description:Inhibition of SERT in rat brain synaptosomes assessed as reduction in [3H]-5-HT uptake measured after 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50452367(CHEMBL4217086)
Affinity DataIC50:  590nMAssay Description:Inhibition of SERT in rat brain synaptosomes assessed as reduction in [3H]-5-HT uptake measured after 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50452368(CHEMBL4215605)
Affinity DataIC50:  840nMAssay Description:Inhibition of SERT in rat brain synaptosomes assessed as reduction in [3H]-5-HT uptake measured after 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50452373(CHEMBL4211687)
Affinity DataIC50:  880nMAssay Description:Inhibition of SERT in rat brain synaptosomes assessed as reduction in [3H]-5-HT uptake measured after 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50452369(CHEMBL4205570)
Affinity DataIC50:  950nMAssay Description:Inhibition of SERT in rat brain synaptosomes assessed as reduction in [3H]-5-HT uptake measured after 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed