Compile Data Set for Download or QSAR
maximum 50k data
Found 16 Enz. Inhib. hit(s) with all data for entry = 50002157
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
King'S College

Curated by ChEMBL
LigandPNGBDBM50454190(CHEMBL4202767)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]-9-cis-retinoic acid from recombinant human full length RXRalpha after 16 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-beta(Homo sapiens (Human))
King'S College

Curated by ChEMBL
LigandPNGBDBM50454190(CHEMBL4202767)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]-9-cis-retinoic acid from recombinant human full length RXRbeta after 24 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
King'S College

Curated by ChEMBL
LigandPNGBDBM50120065(4-[(4-Chloro-3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
King'S College

Curated by ChEMBL
LigandPNGBDBM50454190(CHEMBL4202767)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
King'S College

Curated by ChEMBL
LigandPNGBDBM50120065(4-[(4-Chloro-3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
King'S College

Curated by ChEMBL
LigandPNGBDBM50454190(CHEMBL4202767)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
King'S College

Curated by ChEMBL
LigandPNGBDBM50454190(CHEMBL4202767)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
King'S College

Curated by ChEMBL
LigandPNGBDBM50120065(4-[(4-Chloro-3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
King'S College

Curated by ChEMBL
LigandPNGBDBM50120065(4-[(4-Chloro-3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
King'S College

Curated by ChEMBL
LigandPNGBDBM50454190(CHEMBL4202767)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
King'S College

Curated by ChEMBL
LigandPNGBDBM50120065(4-[(4-Chloro-3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
King'S College

Curated by ChEMBL
LigandPNGBDBM50454190(CHEMBL4202767)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor beta(Mus musculus)
King'S College

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Affinity DataEC50:  0.520nMAssay Description:Transactivation of mouse Gal4-fused RARbeta-LBD expressed in COS-7 cells after 1 day by bright-Glo reagent based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetRetinoic acid receptor alpha(Homo sapiens (Human))
King'S College

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Affinity DataEC50:  1nMAssay Description:Transactivation of human Gal4-DBD-fused RARalpha-LBD expressed in HEK293T cells after 16 to 24 hrs by FRET based beta-lactamase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Mus musculus)
King'S College

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Affinity DataEC50:  0.220nMAssay Description:Transactivation of mouse Gal4-fused RARgamma-LBD expressed in COS-7 cells after 1 day by bright-Glo reagent based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetRetinoic acid receptor alpha(Mus musculus)
King'S College

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Affinity DataEC50:  1.5nMAssay Description:Transactivation of mouse Gal4-fused RARalpha-LBD expressed in COS-7 cells after 1 day by bright-Glo reagent based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed