Found 46 Enz. Inhib. hit(s) with all data for entry = 50003250 
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 50nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant human full length GST-tagged wild type BRAF expressed in baculovirus expression system using recombinant human full length ...More data for this Ligand-Target Pair
Affinity DataIC50: 820nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 3.15E+3nMAssay Description:Inhibition of recombinant human GST-tagged c-RAF (306 to 648 residues) Y340D/Y341D mutant expressed in baculovirus expression system using recombinan...More data for this Ligand-Target Pair
Affinity DataIC50: 4.28E+3nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 5.21E+3nMAssay Description:Inhibition of recombinant human full length GST-tagged wild type BRAF expressed in baculovirus expression system using recombinant human full length ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 5.23E+3nMAssay Description:Inhibition of recombinant human full length GST-tagged wild type BRAF expressed in baculovirus expression system using recombinant human full length ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
Affinity DataIC50: 1.21E+4nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of recombinant human GST-tagged c-RAF (306 to 648 residues) Y340D/Y341D mutant expressed in baculovirus expression system using recombinan...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of recombinant human full length GST-tagged wild type BRAF expressed in baculovirus expression system using recombinant human full length ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 2.13E+4nMAssay Description:Inhibition of recombinant human full length GST-tagged wild type BRAF expressed in baculovirus expression system using recombinant human full length ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 2.31E+4nMAssay Description:Inhibition of recombinant human full length GST-tagged wild type BRAF expressed in baculovirus expression system using recombinant human full length ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.95E+4nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
Affinity DataIC50: 3.06E+4nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 3.56E+4nMAssay Description:Inhibition of recombinant human full length GST-tagged wild type BRAF expressed in baculovirus expression system using recombinant human full length ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.89E+4nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 3.93E+4nMAssay Description:Inhibition of recombinant human full length GST-tagged wild type BRAF expressed in baculovirus expression system using recombinant human full length ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 4.89E+4nMAssay Description:Inhibition of recombinant human full length GST-tagged wild type BRAF expressed in baculovirus expression system using recombinant human full length ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.72E+4nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
Affinity DataIC50: 7.83E+4nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
Affinity DataIC50: 8.43E+4nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
Affinity DataIC50: 8.89E+4nMAssay Description:Inhibition of N-terminal flag-tagged JNK1 (unknown origin) expressed in baculovirus expression system after 60 mins in presence of [gamma-32P]ATP by ...More data for this Ligand-Target Pair
Affinity DataIC50: 9.36E+4nMAssay Description:Inhibition of N-terminal flag-tagged JNK1 (unknown origin) expressed in baculovirus expression system after 60 mins in presence of [gamma-32P]ATP by ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 9.59E+4nMAssay Description:Inhibition of recombinant human full length GST-tagged wild type BRAF expressed in baculovirus expression system using recombinant human full length ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 1.24E+5nMAssay Description:Inhibition of recombinant human full length GST-tagged wild type BRAF expressed in baculovirus expression system using recombinant human full length ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 1.56E+5nMAssay Description:Inhibition of recombinant human full length GST-tagged wild type BRAF expressed in baculovirus expression system using recombinant human full length ...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 1.76E+5nMAssay Description:Inhibition of MEK1/2 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 1.88E+5nMAssay Description:Inhibition of MEK1/2 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 1.95E+5nMAssay Description:Inhibition of MEK1/2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of recombinant human GST-tagged c-RAF (306 to 648 residues) Y340D/Y341D mutant expressed in baculovirus expression system using recombinan...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of N-terminal flag-tagged JNK1 (unknown origin) expressed in baculovirus expression system after 60 mins in presence of [gamma-32P]ATP by ...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of recombinant human full length GST-tagged wild type BRAF expressed in baculovirus expression system using recombinant human full length ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of recombinant human full length GST-tagged wild type BRAF expressed in baculovirus expression system using recombinant human full length ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of recombinant human full length GST-tagged wild type BRAF expressed in baculovirus expression system using recombinant human full length ...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of N-terminal flag-tagged p38alpha (unknown origin) expressed in baculovirus expression system using MBP as substrate preincubated for 5 m...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of recombinant human full length GST-tagged wild type BRAF expressed in baculovirus expression system using recombinant human full length ...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of N-terminal flag-tagged p38alpha (unknown origin) expressed in baculovirus expression system using MBP as substrate preincubated for 5 m...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of recombinant human full length GST-tagged wild type BRAF expressed in baculovirus expression system using recombinant human full length ...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of N-terminal flag-tagged p38alpha (unknown origin) expressed in baculovirus expression system using MBP as substrate preincubated for 5 m...More data for this Ligand-Target Pair
