BindingDB PrimarySearch

Found 11 Enz. Inhib. hit(s) with all data for entry = 50003213

Epidermal growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: 1.20nMAssay Description:Inhibition of recombinant human C-terminal His-tagged/N-terminal GST-tagged EGFR (668 to 1210 residues) T790M/L858R/C797S mutant using poly (Glu,Tyr)...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL

BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)

IC50: 3.40nMAssay Description:Inhibition of recombinant human EGFR T790M/L858R double mutant using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL

BDBM50468192(CHEMBL4294743)

IC50: 5.80nMAssay Description:Inhibition of recombinant human C-terminal His-tagged/N-terminal GST-tagged EGFR (668 to 1210 residues) T790M/L858R/C797S mutant using poly (Glu,Tyr)...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL

BDBM50468192(CHEMBL4294743)

IC50: 6.80nMAssay Description:Inhibition of EGFR (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: 17nMAssay Description:Inhibition of recombinant human EGFR T790M/L858R double mutant using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL

BDBM50468192(CHEMBL4294743)

IC50: 31nMAssay Description:Inhibition of recombinant human EGFR T790M/L858R double mutant using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL

BDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)

IC50: 38nMAssay Description:Inhibition of recombinant human C-terminal His-tagged/N-terminal GST-tagged EGFR (668 to 1210 residues) T790M/L858R/C797S mutant using poly (Glu,Tyr)...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase MCE
PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL

BDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)

IC50: 51nMAssay Description:Inhibition of recombinant human EGFR T790M/L858R double mutant using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase MCE
PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL

BDBM50453890(CHEMBL4218431)

IC50: 85nMAssay Description:Inhibition of recombinant human C-terminal His-tagged/N-terminal GST-tagged EGFR (668 to 1210 residues) T790M/L858R/C797S mutant using poly (Glu,Tyr)...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Epidermal growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL

BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)

IC50: 225nMAssay Description:Inhibition of recombinant human C-terminal His-tagged/N-terminal GST-tagged EGFR (668 to 1210 residues) T790M/L858R/C797S mutant using poly (Glu,Tyr)...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase DrugBank MCE
PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL

BDBM50453890(CHEMBL4218431)

IC50: 367nMAssay Description:Inhibition of recombinant human EGFR T790M/L858R double mutant using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed