Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50008625
TargetProprotein convertase subtilisin/kexin type 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50520946(CHEMBL4544205)
Affinity DataKd:  24nMAssay Description:Binding affinity to human recombinant PCSK9 by backscatter interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50520947(CHEMBL4458097)
Affinity DataIC50: 500nMAssay Description:Inhibition of His-tagged PCSK9 (unknown origin) binding to recombinant LDLR-AB domain (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275436(CHEMBL4128250)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human recombinant full length ProLabel-tagged PCSK9 expressed in CHO-K1 cells incubated overnight and measured after 3 days by HTS assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50520945(CHEMBL4584571)
Affinity DataEC50:  6.04E+3nMAssay Description:Inhibition of PCSK9 in human HepG2 cells assessed as increase in LDL uptake after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275436(CHEMBL4128250)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant PCSK9 expressed in CHO-K1 cells assessed as alkaline phosphatase secretion incubated overnight and measured after 3 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275436(CHEMBL4128250)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length ProLabel-tagged PCSK9 expressed in CHO-K1 cells incubated overnight and measured after 3 days by chemilum...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50520945(CHEMBL4584571)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of wild type His-tagged PCSK9 (unknown origin) binding to recombinant LDLR-AB domain (unknown origin) after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50520944(CHEMBL4440808)
Affinity DataKd:  2.48E+4nMAssay Description:Binding affinity to PCSK9 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50520943(CHEMBL4460894)
Affinity DataKd:  3.58E+4nMAssay Description:Binding affinity to PCSK9 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50520942(CHEMBL4447311)
Affinity DataKd:  4.12E+4nMAssay Description:Binding affinity to PCSK9 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50179360(CHEMBL3040216)
Affinity DataKd:  1.90E+5nMAssay Description:Inhibition of PCSK9 in human HepG2 cells assessed as increase in LDLR levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed