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Found 8 Enz. Inhib. hit(s) with all data for entry = 50007593
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
India

Curated by ChEMBL
LigandPNGBDBM50510763(CHEMBL2218927)
Affinity DataIC50:  90nMAssay Description:Inhibition of human PDGFR betaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
India

Curated by ChEMBL
LigandPNGBDBM7534(1H-pyrazolo[3,4-b]quinoxalin-3-amine | pyrazolo[3,...)
Affinity DataIC50:  400nMAssay Description:Inhibition of CDK5/p25 (unknown origin) expressed in Escherichia coli using histone as substrate in presence of [gamma32P]ATP after 10 mins by scinti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
India

Curated by ChEMBL
LigandPNGBDBM50510763(CHEMBL2218927)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of c-KIT in human M-07e cells assessed as reduction in tyrphostin activity incubated for 2 hrs followed by KIT ligand stimulation by immun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
India

Curated by ChEMBL
LigandPNGBDBM50510763(CHEMBL2218927)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human FLT3 expressed in mouse BAF3 cells assessed as reduction in tyrphostin activity incubated for 2 hrs followed by FLT3 ligand stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
India

Curated by ChEMBL
LigandPNGBDBM7534(1H-pyrazolo[3,4-b]quinoxalin-3-amine | pyrazolo[3,...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of GSK3beta (unknown origin) using GS-1 peptide as a substrate after 30 mins in presence of [gamma32P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Mus musculus (Mouse))
India

Curated by ChEMBL
LigandPNGBDBM50510763(CHEMBL2218927)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of SRC in transformed mouse NIH3T3 cells by SDS-PAGE based immunoblot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
India

Curated by ChEMBL
LigandPNGBDBM50510763(CHEMBL2218927)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of EGFR in human A431 cells incubated for 2 hrs followed by EGF stimulation and measured after 10 mins by immunoblot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
India

Curated by ChEMBL
LigandPNGBDBM50510763(CHEMBL2218927)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of IGFR1 (unknown origin) using poly (Glu,Tyr) 4:1 as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed