Compile Data Set for Download or QSAR
maximum 50k data
Found 56 Enz. Inhib. hit(s) with all data for entry = 50011238
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368552(N-(1H-pyrazolo[4,3-b] pyridin- 3-yl)isoquinolin-6-...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368526(1-(difluoromethyl)-N- (1H-pyrazolo [4,3-b]pyridin-...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368552(N-(1H-pyrazolo[4,3-b] pyridin- 3-yl)isoquinolin-6-...)
Affinity DataIC50:  440nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368549(1-ethyl-N-(1H-pyrazolo [4,3-b]pyridin- 3-yl)isoqui...)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368548(1-cyclopropyl-N-(1H- pyrazolo[4,3-b]pyridin-3- yl)...)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368552(N-(1H-pyrazolo[4,3-b] pyridin- 3-yl)isoquinolin-6-...)
Affinity DataIC50:  1.35E+3nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368542(1-(1H-pyrazol-1-yl)-N- (1H- pyrazolo[4,3-b]pyridin...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50078637(CHEMBL4784617)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368552(N-(1H-pyrazolo[4,3-b] pyridin- 3-yl)isoquinolin-6-...)
Affinity DataIC50:  3.98E+3nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368542(1-(1H-pyrazol-1-yl)-N- (1H- pyrazolo[4,3-b]pyridin...)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368542(1-(1H-pyrazol-1-yl)-N- (1H- pyrazolo[4,3-b]pyridin...)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368542(1-(1H-pyrazol-1-yl)-N- (1H- pyrazolo[4,3-b]pyridin...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50078637(CHEMBL4784617)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368526(1-(difluoromethyl)-N- (1H-pyrazolo [4,3-b]pyridin-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50078637(CHEMBL4784617)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368526(1-(difluoromethyl)-N- (1H-pyrazolo [4,3-b]pyridin-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368526(1-(difluoromethyl)-N- (1H-pyrazolo [4,3-b]pyridin-...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368515(N-(1H-pyrazolo[3,4- b]pyrazin-3-yl)-1- (trifluorom...)
Affinity DataIC50: <5.00E+5nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368520(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataIC50: <5.00E+5nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50078640(CHEMBL4755785)
Affinity DataEC50:  653nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50078641(CHEMBL4750744)
Affinity DataEC50:  1.73E+3nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368520(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50:  18nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368515(N-(1H-pyrazolo[3,4- b]pyrazin-3-yl)-1- (trifluorom...)
Affinity DataEC50:  51nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50:  65nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368553(N-(naphthalen-2-yl)-1H- pyrazolo[4,3-b]pyridin-3- ...)
Affinity DataEC50:  403nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368552(N-(1H-pyrazolo[4,3-b] pyridin- 3-yl)isoquinolin-6-...)
Affinity DataEC50:  76nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50147621(CHEMBL4788007)
Affinity DataEC50:  732nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50148372(CHEMBL4795205)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50148374(CHEMBL4760038)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50148375(CHEMBL4800673)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50148385(CHEMBL4753444)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50148386(CHEMBL4745063)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50:  197nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50:  195nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50078639(CHEMBL4762098)
Affinity DataEC50:  685nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50078638(CHEMBL4764520)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50078637(CHEMBL4784617)
Affinity DataEC50:  264nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368511(1-(1-methyl-3- (trifluoromethyl)-1H- pyrazol-5-yl)...)
Affinity DataEC50:  132nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368512(1-(1-methyl-1H-pyrazol- 5-yl)-N-(1H-pyrazolo [4,3-...)
Affinity DataEC50:  45nMAssay Description:Inhibition of human urine urokinase using L-PyroGlu-Gly-Arg-pNA.HCl substrate at 5 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368518(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1-(1,1,1- trif...)
Affinity DataEC50:  36nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368526(1-(difluoromethyl)-N- (1H-pyrazolo [4,3-b]pyridin-...)
Affinity DataEC50:  8nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368548(1-cyclopropyl-N-(1H- pyrazolo[4,3-b]pyridin-3- yl)...)
Affinity DataEC50:  71nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368549(1-ethyl-N-(1H-pyrazolo [4,3-b]pyridin- 3-yl)isoqui...)
Affinity DataEC50:  45nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368521(1-(3,5-dimethyl-1H- pyrazol-1-yl)-N- (1H-pyrazolo[...)
Affinity DataEC50:  726nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50078636(CHEMBL4782314)
Affinity DataEC50:  237nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368542(1-(1H-pyrazol-1-yl)-N- (1H- pyrazolo[4,3-b]pyridin...)
Affinity DataEC50:  63nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368537(1-(3,3-difluoropyrrolidin- 1-yl)-N-(1H- pyrazolo[4...)
Affinity DataEC50:  249nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368531(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1-(2- (trifluo...)
Affinity DataEC50:  306nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50078635(CHEMBL4797966 | US11242342, Compound 23)
Affinity DataEC50:  121nMAssay Description:Inhibition of human plasmin using pyroGlu-Phe-Lys-pNA.HClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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