Found 24 Enz. Inhib. hit(s) with all data for entry = 50009547 TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminal His-tagged human TAK1 (1 to 303 amino acids)/human TAB1 (437 to 504 amino acids) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant FLAG-tagged TAK1 (unknown origin) co-expressed with TAB (unknown origin) in baculovirus using BT-MKK as substrate after 1 h...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant FLAG-tagged TAK1 (unknown origin) co-expressed with TAB (unknown origin) in baculovirus using BT-MKK as substrate after 1 h...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminal His-tagged human TAK1 (1 to 303 amino acids)/human TAB1 (437 to 504 amino acids) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of full length TAK1/TAB1 (unknown origin) using biotin-MKK6 as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of full length TAK1/TAB1 (unknown origin) using biotin-MKK6 as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of N-terminal His-tagged human TAK1 (1 to 303 amino acids)/human TAB1 (437 to 504 amino acids) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of N-terminal His-tagged human TAK1 (1 to 303 amino acids)/human TAB1 (437 to 504 amino acids) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of N-terminal His-tagged human TAK1 (1 to 303 amino acids)/human TAB1 (437 to 504 amino acids) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of N-terminal His-tagged human TAK1 (1 to 303 amino acids)/human TAB1 (437 to 504 amino acids) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 156nMAssay Description:Inhibition of TAK1 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 156nMAssay Description:Inhibition of TAK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of CYP2C9 in liver microsomes (unknown origin) using sulfaphenazole as substrate preincubated for 5 mins followed by NADPH addition and me...More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of CYP2C9 in liver microsomes (unknown origin) using sulfaphenazole as substrate preincubated for 5 mins followed by NADPH addition and me...More data for this Ligand-Target Pair
Affinity DataIC50: 3.52E+3nMAssay Description:Inhibition of CYP3A4 in liver microsomes (unknown origin) using ketoconazole as substrate preincubated for 5 mins followed by NADPH addition and meas...More data for this Ligand-Target Pair
Affinity DataIC50: 3.52E+3nMAssay Description:Inhibition of CYP3A4 in liver microsomes (unknown origin) using ketoconazole as substrate preincubated for 5 mins followed by NADPH addition and meas...More data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2B6 in liver microsomes (unknown origin) using clopidogrel as substrate preincubated for 5 mins followed by NADPH addition and measu...More data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in liver microsomes (unknown origin) using (+/-) N-3-benzylnirvanol as substrate preincubated for 5 mins followed by NADPH addi...More data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP1A2 in liver microsomes (unknown origin) using alpha-naphthoflavone as substrate preincubated for 5 mins followed by NADPH addition ...More data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP1A2 in liver microsomes (unknown origin) using alpha-naphthoflavone as substrate preincubated for 5 mins followed by NADPH addition ...More data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in liver microsomes (unknown origin) using (+/-) N-3-benzylnirvanol as substrate preincubated for 5 mins followed by NADPH addi...More data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2B6 in liver microsomes (unknown origin) using clopidogrel as substrate preincubated for 5 mins followed by NADPH addition and measu...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Binding affinity to human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Binding affinity to human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
