Compile Data Set for Download or QSAR
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Found 14 Enz. Inhib. hit(s) with all data for entry = 50009047
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50524833(CHEMBL283631 | NSC-628679)
Affinity DataIC50:  1nMAssay Description:Inhibition of HIF-1alpha in human U373 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50510124(CHEMBL3186774)
Affinity DataIC50:  22nMAssay Description:Inhibition of human PHD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50524837(CHEMBL4441544)
Affinity DataIC50:  100nMAssay Description:Inhibition of GST-tagged p300 (unknown origin)/CBP (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50524835(CHEMBL4468788)
Affinity DataIC50:  600nMAssay Description:Inhibition of GST-tagged p300 (unknown origin)/CBP (unknown origin) protein-protein interaction by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50014097(CHEMBL3260851)
Affinity DataIC50:  900nMAssay Description:Inhibition of VHL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetCREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50524836(CHEMBL4555267)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of GST-tagged p300 (unknown origin)/CBP (unknown origin) protein-protein interaction by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM76423(2-(4-methylphenyl)-2-oxoethyl 3-({2,4-dinitrobenzo...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of HIF-1alpha in human HeLa cells after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50315537(CHEMBL1089316 | chaetocin)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of N-terminal biotinylated HIF-1alpha (786 to 826 residues) (unknown origin)/GST-tagged p300-CH1 domain (unknown origin) protein-protein i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50524838(CHEMBL4458726)
Affinity DataIC50:  7.50E+4nMAssay Description:Inhibition of HIF-1alpha- CTAD domain (unknown origin)/p300-CH1 domain (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50485362(CHEMBL2057226)
Affinity DataIC50:  1.07E+5nMAssay Description:Inhibition of GST-tagged p300 (unknown origin)/CBP (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50524834(CHEMBL4435255)
Affinity DataKd:  690nMAssay Description:Binding affinity to p300 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha inhibitor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM26107((2R)-2-(formamidoformic acid)-3-phenylpropanoic ac...)
Affinity DataKd:  8.30E+4nMAssay Description:Inhibition of FIH (unknown origin)More data for this Ligand-Target Pair
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataKd:  90nMAssay Description:Binding affinity to VHL (unknown origin)More data for this Ligand-Target Pair
TargetHistone acetyltransferase p300(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50524839(CHEMBL4466328)
Affinity DataKd:  530nMAssay Description:Binding affinity to p300-CH1 domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed