Compile Data Set for Download or QSAR
maximum 50k data
Found 32 Enz. Inhib. hit(s) with all data for entry = 50010265
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataKi:  0.900nMAssay Description:Inhibition of PARP2 (unknown origin) after 1 min in presence of NAD by top count analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataKi:  1.20nMAssay Description:Inhibition of PARP1 (unknown origin) after 1 min in presence of NAD by top count analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human recombinant full-length PARP1 after 4 mins by [32P]NAD+ incorporation assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataKi:  3.20nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataKi:  4nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50068774(8-HYDROXY-2-METHYL-3-HYDRO-QUINAZOLIN-4-ONE | 8-Hy...)
Affinity DataKi:  48nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM27506(3-AB | 3-aminobenzamide | CHEMBL81977)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM206061(US9255106, S3)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of recombinant human PARP2 using histone as substrate after 1 hr in presence of NAD+ by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of PARP1 (unknown origin) after 1 min in presence of NAD by top count analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Mus musculus (Mouse))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536937(CHEMBL4554200)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of mouse recombinant PARP2 by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM206061(US9255106, S3)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of PARP1 (unknown origin) by NAD+ based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536939(CHEMBL4569417)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PARP1 (unknown origin) using histone as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM206061(US9255106, S3)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of recombinant human PARP1 using histone as substrate after 1 hr in presence of NAD+ by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536936(CHEMBL4584534)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of PARP2 (unknown origin) by biotinylated NAD+-based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536936(CHEMBL4584534)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of recombinant human PARP1 using histone as substrate after 1 hr in presence of NAD+ by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human recombinant full-length PARP1 after 4 mins by [32P]NAD+ incorporation assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536937(CHEMBL4554200)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human recombinant PARP1 by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536942(CHEMBL4569989)
Affinity DataIC50:  10nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536939(CHEMBL4569417)
Affinity DataIC50:  11nMAssay Description:Inhibition of PARP2 (unknown origin) using histone as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536935(CHEMBL4533690)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant PARP1 by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536935(CHEMBL4533690)
Affinity DataIC50:  68nMAssay Description:Inhibition of human recombinant PARP2 by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536941(CHEMBL4521985)
Affinity DataIC50:  79nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536938(CHEMBL4521684)
Affinity DataIC50:  97nMAssay Description:Inhibition of PARP1 (unknown origin) by colorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536937(CHEMBL4554200)
Affinity DataIC50:  133nMAssay Description:Inhibition of human recombinant TNKS1 by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536937(CHEMBL4554200)
Affinity DataIC50:  290nMAssay Description:Inhibition of human recombinant TNKS2 by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM27682(5-methyl-1,2,3,4-tetrahydroisoquinolin-1-one | CHE...)
Affinity DataIC50:  420nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536943(CHEMBL4557319)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of PARP1 (unknown origin) using HRP as substrate preincubated for 60 mins followed by compound wash and substrate addition and measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50249337(CHEMBL4099515)
Affinity DataIC50:  7.40E+4nMAssay Description:Inhibition of PARP1 (unknown origin) using Strep-HRP as substrate preincubated for 60 mins followed by compound wash and substrate addition and measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536944(CHEMBL4453320)
Affinity DataIC50:  9.00E+5nMAssay Description:Inhibition of human recombinant PARP1 using radiolabeled [3H]substrate after 1 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536940(CHEMBL4469504)
Affinity DataIC50:  4.20E+6nMAssay Description:Inhibition of human recombinant PARP1 using radiolabeled [3H]substrate after 1 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed