Found 12 Enz. Inhib. hit(s) with all data for entry = 50009208 TargetHistone-lysine N-methyltransferase SETD7(Homo sapiens (Human))
Punjabi University
Curated by ChEMBL
Punjabi University
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant full-length human SETD7 (1 to 366 residues) expressed in Escherichia coli BL21 (DE3) using [3H]-SAM-fused biotinylated pept...More data for this Ligand-Target Pair
3D Structure (crystal)TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Punjabi University
Curated by ChEMBL
Punjabi University
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin) using dimethylated H3K27 as substrateMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Punjabi University
Curated by ChEMBL
Punjabi University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of EZH2 (unknown origin) using unmethylated H3K27 (21 to 44 residues) as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: <15nMAssay Description:Inhibition of SMYD2 (unknown origin) using [3H]-p53 (361 to 380 residues) as substrate after 1 hr in presence of [3H]-SAM by scintillation proximity ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Punjabi University
Curated by ChEMBL
Punjabi University
Curated by ChEMBL
Affinity DataIC50: <100nMAssay Description:Inhibition of DOT1L in human THP1 cells assessed as reduction in H3K79 methylation measured after 7 daysMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Punjabi University
Curated by ChEMBL
Punjabi University
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of GST-tagged EHMT2 (unknown origin) using biotinylated-H3 peptide as substrate preincubated for 1 hr followed by substrate addition and m...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Punjabi University
Curated by ChEMBL
Punjabi University
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of GST-tagged EHMT2 (unknown origin) using biotinylated-H3 peptide as substrate preincubated for 1 hr followed by substrate addition and m...More data for this Ligand-Target Pair
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of SETD8 (unknown origin) using biotinylated-H3 peptide as substrate measured after 1 hr in presence of [3H]-SAM by scintillation proximit...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Punjabi University
Curated by ChEMBL
Punjabi University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of EHMT2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Punjabi University
Curated by ChEMBL
Punjabi University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Punjabi University
Curated by ChEMBL
Punjabi University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CARM1 (unknown origin)More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Punjabi University
Curated by ChEMBL
Punjabi University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
