Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50008700
TargetAcetylcholinesterase(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50521366(CHEMBL4569343)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50079362(CHEMBL3417009 | US9663465, 9)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]GR113808 from human 5-HT4R membrane in Tris buffer assessed as inhibitory constant measured after 60 mins by filter binding metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50079362(CHEMBL3417009 | US9663465, 9)
Affinity DataIC50: 16nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate incubated for 5 mins followed by substrate addition by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMicrotubule-associated protein tau(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50521365(CHEMBL4543631)
Affinity DataKi:  120nMAssay Description:Inhibition of tau aggregation (unknown origin) assessed as inhibitory constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMicrotubule-associated protein tau(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50241461(Methylene Blue anhydrous | Methylenblau | bleu de ...)
Affinity DataEC50:  130nMAssay Description:Inhibition of tau-tau binding (unknown origin) assessed as increase in dissolved paired helical filamentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMicrotubule-associated protein tau(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50521365(CHEMBL4543631)
Affinity DataIC50: 160nMAssay Description:Inhibition of tau aggregation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50067482(CHEMBL11805 | CHEMBL222856 | CHEMBL557586 | N,N''-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50521367(CHEMBL3585374)
Affinity DataIC50: 195nMAssay Description:Inhibition of human AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50521366(CHEMBL4569343)
Affinity DataIC50: 232nMAssay Description:Inhibition of human BuChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50134399(1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione | 7...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant BACE-1 using 19F peptide as substrate measured after 5 hrs by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50513226(CHEMBL4475303)
Affinity DataIC50: 520nMAssay Description:Inhibition of BChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMicrotubule-associated protein tau(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50241461(Methylene Blue anhydrous | Methylenblau | bleu de ...)
Affinity DataEC50:  590nMAssay Description:Inhibition of tau aggregation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50134399(1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione | 7...)
Affinity DataIC50: 700nMAssay Description:Inhibition of human recombinant GSK-3beta using 19F peptide as substrate measured after 1.5 hrs by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50521367(CHEMBL3585374)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50067482(CHEMBL11805 | CHEMBL222856 | CHEMBL557586 | N,N''-...)
Affinity DataIC50: 1.17E+4nMAssay Description:Inhibition of BuChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50513226(CHEMBL4475303)
Affinity DataIC50: 1.46E+4nMAssay Description:Displacement of [3H]MK-801 from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataIC50: 7.90E+6nMAssay Description:Inhibition of BuChE (unknown origin) assessed as decrease in thiocholine accumulation by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Jining Medical University

Curated by ChEMBL
LigandPNGBDBM50305261(Dimebolin | CHEMBL589390)
Affinity DataEC50:  2.50E+7nMAssay Description:Inhibition of self-induced amyloid beta (1 to 42) (unknown origin) aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed