Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50009073
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PDE4D (unknown origin) using cAMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataIC50: 70nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential measured after 3 mins by QPatch automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50248919((S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsu...)
Affinity DataIC50: 74nMAssay Description:Inhibition of PDE4D (unknown origin) using cAMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525177(CHEMBL4532140 | US12145923, Compound (S)-C7)
Affinity DataIC50: 98nMAssay Description:Inhibition of recombinant human PDE4D catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50248919((S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsu...)
Affinity DataIC50: 110nMAssay Description:Inhibition of PDE4 in human PBMC assessed as reduction in LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50: 120nMAssay Description:Inhibition of PDE4D (unknown origin) using cAMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525166(CHEMBL4543264 | US12145923, Compound (S)-A4)
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant human PDE4D catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 240nMAssay Description:Inhibition of PDE4D (unknown origin) using cAMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525165(CHEMBL4527894 | US12145923, Compound (S)-C5)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant human PDE4D catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525174(CHEMBL4592339 | US12145923, Compound (S)-C6)
Affinity DataIC50: 250nMAssay Description:Inhibition of recombinant human PDE4D catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525175(CHEMBL4520636 | US12145923, Compound (S)-A1)
Affinity DataIC50: 270nMAssay Description:Inhibition of recombinant human PDE4D catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525167(CHEMBL4556365)
Affinity DataIC50: 510nMAssay Description:Inhibition of recombinant human PDE4D catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525176(CHEMBL4466435 | US12145923, Compound (S)-C9)
Affinity DataIC50: 650nMAssay Description:Inhibition of recombinant human PDE4D catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525165(CHEMBL4527894 | US12145923, Compound (S)-C5)
Affinity DataIC50: 650nMAssay Description:Inhibition of PDE4 in human PBMC assessed as reduction in LPS-stimulated TNFalpha production preincubated for 1 hr followed by LPS stimulation and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525172(CHEMBL4443701 | US12145923, Compound (S)-C4)
Affinity DataIC50: 700nMAssay Description:Inhibition of recombinant human PDE4D catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525164(CHEMBL4536368 | US12145923, Compound (S)-A3)
Affinity DataIC50: 820nMAssay Description:Inhibition of recombinant human PDE4D catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525165(CHEMBL4527894 | US12145923, Compound (S)-C5)
Affinity DataIC50: 920nMAssay Description:Inhibition of recombinant human PDE10A catalytic domain using [3H]cGMP or [3H]cAMP as substrate measured after 30 mins by scintillation proximity ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525172(CHEMBL4443701 | US12145923, Compound (S)-C4)
Affinity DataIC50: 2.16E+3nMAssay Description:Inhibition of PDE4 in human PBMC assessed as reduction in LPS-stimulated TNFalpha production preincubated for 1 hr followed by LPS stimulation and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525164(CHEMBL4536368 | US12145923, Compound (S)-A3)
Affinity DataIC50: 2.58E+3nMAssay Description:Inhibition of PDE4 in human PBMC assessed as reduction in LPS-stimulated TNFalpha production preincubated for 1 hr followed by LPS stimulation and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525166(CHEMBL4543264 | US12145923, Compound (S)-A4)
Affinity DataIC50: 2.71E+3nMAssay Description:Inhibition of PDE4 in human PBMC assessed as reduction in LPS-stimulated TNFalpha production preincubated for 1 hr followed by LPS stimulation and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525175(CHEMBL4520636 | US12145923, Compound (S)-A1)
Affinity DataIC50: 2.73E+3nMAssay Description:Inhibition of PDE4 in human PBMC assessed as reduction in LPS-stimulated TNFalpha production preincubated for 1 hr followed by LPS stimulation and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525165(CHEMBL4527894 | US12145923, Compound (S)-C5)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PDE6C expressed in baculovirus infected Sf9 insect cells using [3H]cGMP as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525171(CHEMBL4445498)
Affinity DataIC50: 3.71E+3nMAssay Description:Inhibition of recombinant human PDE4D catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525170(CHEMBL4572934)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of recombinant human PDE4D catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525165(CHEMBL4527894 | US12145923, Compound (S)-C5)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human PDE5A catalytic domain using [3H]cGMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525165(CHEMBL4527894 | US12145923, Compound (S)-C5)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human PDE7A catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525174(CHEMBL4592339 | US12145923, Compound (S)-C6)
Affinity DataIC50: 5.83E+3nMAssay Description:Inhibition of PDE4 in human PBMC assessed as reduction in LPS-stimulated TNFalpha production preincubated for 1 hr followed by LPS stimulation and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525169(CHEMBL4440925)
Affinity DataIC50: 2.07E+4nMAssay Description:Inhibition of recombinant human PDE4D catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525173(CHEMBL4525913)
Affinity DataIC50: 2.61E+4nMAssay Description:Inhibition of recombinant human PDE4D catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525165(CHEMBL4527894 | US12145923, Compound (S)-C5)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential measured after 3 mins by QPatch automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525165(CHEMBL4527894 | US12145923, Compound (S)-C5)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PDE8A1 expressed in baculovirus infected Sf9 insect cells using [3H]cAMP as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525165(CHEMBL4527894 | US12145923, Compound (S)-C5)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PDE11A4 expressed in baculovirus infected Sf9 insect cells using [3H]cAMP as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50525165(CHEMBL4527894 | US12145923, Compound (S)-C5)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PDE1A5 expressed in baculovirus infected Sf9 insect cells using [3H]cAMP as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525165(CHEMBL4527894 | US12145923, Compound (S)-C5)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human full length N-terminal thrombin cleavage site-fused/GST-tagged PDE2A expressed in baculovirus infected Sf9 insect cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525165(CHEMBL4527894 | US12145923, Compound (S)-C5)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human PDE9A catalytic domain using [3H]cGMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525168(CHEMBL4455732)
Affinity DataIC50: 5.85E+4nMAssay Description:Inhibition of recombinant human PDE4D catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)