Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 50007842
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM14777(CHEMBL779 | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-m...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PDE5A1 (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513221(CHEMBL4455013)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of recombinant human AChE using acetylthiocholine as substrate by UV-visible absorption methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50359391(CHEMBL1929421)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of rat liver mitochondrial MAOA [14C]-5-HT as substrate preincubated for 30 mins followed by substrate addition by liquid scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513221(CHEMBL4455013)
Affinity DataIC50: 18nMAssay Description:Inhibition of BACE-1 (unknown origin) after 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 32nMAssay Description:Inhibition of AChE from rat cortex by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50359391(CHEMBL1929421)
Affinity DataIC50: 43nMAssay Description:Inhibition of rat liver mitochondrial MAOB using [14C]-PEA as substrate preincubated for 30 mins followed by substrate addition by liquid scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50359390(CHEMBL2022924 | CHEMBL1929418)
Affinity DataIC50: 63nMAssay Description:Inhibition of rat liver mitochondrial MAOB using [14C]-PEA as substrate preincubated for 30 mins followed by substrate addition by liquid scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50359390(CHEMBL2022924 | CHEMBL1929418)
Affinity DataIC50: 100nMAssay Description:Inhibition of rat liver mitochondrial MAOA [14C]-5-HT as substrate preincubated for 30 mins followed by substrate addition by liquid scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513223(CHEMBL4467520)
Affinity DataIC50: 195nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50359391(CHEMBL1929421)
Affinity DataIC50: 350nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50359391(CHEMBL1929421)
Affinity DataIC50: 460nMAssay Description:Inhibition of BACE-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513224(CHEMBL4442213)
Affinity DataIC50: 490nMAssay Description:Irreversible inhibition of MAOA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCholinesterase(Horse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513226(CHEMBL4475303)
Affinity DataIC50: 520nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50145909(CHEMBL3763944)
Affinity DataIC50: 900nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513222(CHEMBL4445075)
Affinity DataIC50: 970nMAssay Description:Inhibition of BACE-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513224(CHEMBL4442213)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant human AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM36551(Chelator, M30 | US9034303, M30)
Affinity DataIC50: 1.50E+3nMAssay Description:Mixed type inhibition of MAOB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of PDE5A1 (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM36551(Chelator, M30 | US9034303, M30)
Affinity DataIC50: 1.60E+3nMAssay Description:Irreversible inhibition of BACE-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM36551(Chelator, M30 | US9034303, M30)
Affinity DataIC50: 1.80E+3nMAssay Description:Irreversible inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513224(CHEMBL4442213)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of recombinant human BACE-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50145909(CHEMBL3763944)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of BACE-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513225(CHEMBL4527805)
Affinity DataIC50: 3.44E+3nMAssay Description:Inhibition of human MAOB using benzylamine as substrate preincubated fore 15 mins followed by substrate addition measured after 20 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 3.88E+3nMAssay Description:Inhibition of BuChE from rat serum by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513225(CHEMBL4527805)
Affinity DataIC50: 3.94E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM36551(Chelator, M30 | US9034303, M30)
Affinity DataIC50: 6.20E+3nMAssay Description:Irreversible inhibition of MAOA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513222(CHEMBL4445075)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM36551(Chelator, M30 | US9034303, M30)
Affinity DataIC50: 1.02E+4nMAssay Description:Irreversible inhibition of MAOB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513223(CHEMBL4467520)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513226(CHEMBL4475303)
Affinity DataIC50: 1.34E+4nMAssay Description:Displacement of [3H]-ifenprodil from NMDA receptor (unknown origin) by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513226(CHEMBL4475303)
Affinity DataIC50: 1.46E+4nMAssay Description:Displacement of [3H]-MK-801 from NMDA receptor (unknown origin) by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM14777(CHEMBL779 | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-m...)
Affinity DataIC50: 2.62E+4nMAssay Description:Inhibition of AChE from rat cortex by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513227(CHEMBL4547969)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of PDE9 catalytic domain (unknown origin) using [3H]cAMP or [3H]cGMP as substrate by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513224(CHEMBL4442213)
Affinity DataIC50: 5.39E+4nMAssay Description:Irreversible inhibition of MAOB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM36551(Chelator, M30 | US9034303, M30)
Affinity DataIC50: 5.70E+4nMAssay Description:Mixed type inhibition of MAOA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50435960(CHEMBL2391486)
Affinity DataIC50: 9.20E+4nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine as substrate measured for 3.2 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE2A1 (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE3A (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE9A2 (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE6C (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE7A (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed