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Found 7 Enz. Inhib. hit(s) with all data for entry = 50007844
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Central University Of Punjab

Curated by ChEMBL
LigandPNGBDBM50513256(CHEMBL4442995)
Affinity DataIC50:  620nMAssay Description:Inhibition of P-gp in HEK293/ABCB1 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 1 uM incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Central University Of Punjab

Curated by ChEMBL
LigandPNGBDBM50513257(CHEMBL4215931)
Affinity DataIC50:  700nMAssay Description:Inhibition of P-gp in human NCI-H460/R cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring reduction in doxorubicin IC50 ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Central University Of Punjab

Curated by ChEMBL
LigandPNGBDBM50513256(CHEMBL4442995)
Affinity DataIC50:  920nMAssay Description:Inhibition of P-gp in HEK293/ABCB1 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring cisplatin IC50 at 2 uM incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Central University Of Punjab

Curated by ChEMBL
LigandPNGBDBM50367247(QUININE | Quinamm | Quinsan | cid_3034034)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of P-gp-mediated Rhodamine-123 efflux in human MCF-7/DOX cells assessed as Rhodamine-123 accumulation preincubated for 15 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Central University Of Punjab

Curated by ChEMBL
LigandPNGBDBM50418089(Limonin)
Affinity DataIC50:  1.91E+4nMAssay Description:Inhibition of P-gp in human Caco2 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring reduction in doxorubicin IC50 at 2....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Central University Of Punjab

Curated by ChEMBL
LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | 3,7-dihy...)
Affinity DataIC50:  1.25E+7nMAssay Description:Inhibition of P-gp in human HK2 cells assessed as Rhodamine-123 accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Central University Of Punjab

Curated by ChEMBL
LigandPNGBDBM50042987((E)-1-(2,4-Dihydroxy-phenyl)-3-phenyl-propenone | ...)
Affinity DataIC50:  2.49E+7nMAssay Description:Inhibition of P-gp in human HK2 cells assessed as Rhodamine-123 accumulation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed