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Found 6 Enz. Inhib. hit(s) with all data for entry = 50008864
TargetHistone deacetylase 1(Homo sapiens (Human))
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of recombinant human full-length C-terminal FLAG-tagged HDAC1 expressed in baculovirus expression system using Ac-peptide-AMC as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50522998(CHEMBL4549278)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of recombinant human full-length C-terminal FLAG-tagged HDAC1 expressed in baculovirus expression system using Ac-peptide-AMC as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50522999(CHEMBL4476140)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant human full-length C-terminal FLAG-tagged HDAC1 expressed in baculovirus expression system using Ac-peptide-AMC as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50522998(CHEMBL4549278)
Affinity DataIC50:  56nMAssay Description:Inhibition of wild-type human N-terminal GST-tagged CDK2/cycA2 expressed in Sf21 insect cells using FAM-labelled substrate preincubated for 10 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50522999(CHEMBL4476140)
Affinity DataIC50:  127nMAssay Description:Inhibition of wild-type human N-terminal GST-tagged CDK2/cycA2 expressed in Sf21 insect cells using FAM-labelled substrate preincubated for 10 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Affinity DataIC50:  193nMAssay Description:Inhibition of wild-type human N-terminal GST-tagged CDK2/cycA2 expressed in Sf21 insect cells using FAM-labelled substrate preincubated for 10 mins f...More data for this Ligand-Target Pair