BindingDB PrimarySearch

Found 65 Enz. Inhib. hit(s) with all data for entry = 50006743

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502852(CHEMBL4464755)

IC50: 220nMAssay Description:Inhibition of PDE4B in human U937 cells using [3H] cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502858(CHEMBL4451855)

IC50: 380nMAssay Description:Inhibition of PDE4B in human U937 cells using [3H] cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502854(CHEMBL4574643)

IC50: 1.05E+3nMAssay Description:Inhibition of PDE4B in human U937 cells using [3H] cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502852(CHEMBL4464755)

IC50: 1.36E+3nMAssay Description:Inhibition of PDE4B in human PBMC assessed as inhibition in LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation for ...More data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502858(CHEMBL4451855)

IC50: 1.65E+3nMAssay Description:Inhibition of PDE4B in human PBMC assessed as inhibition in LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation for ...More data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)

IC50: 1.69E+3nMAssay Description:Inhibition of PDE4D in human U937 cells using [3H]cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

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3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)

IC50: 1.82E+3nMAssay Description:Inhibition of PDE4B in human U937 cells using [3H] cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502864(CHEMBL4571089)

IC50: 1.85E+3nMAssay Description:Inhibition of PDE4B in human U937 cells using [3H] cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502853(CHEMBL4578186)

IC50: 1.85E+3nMAssay Description:Inhibition of PDE4B in human U937 cells using [3H] cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502859(CHEMBL4585341)

IC50: 2.03E+3nMAssay Description:Inhibition of PDE4B in human U937 cells using [3H] cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502865(CHEMBL4470613)

IC50: 3.86E+3nMAssay Description:Inhibition of PDE4B in human U937 cells using [3H] cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502867(CHEMBL4447428)

IC50: 3.96E+3nMAssay Description:Inhibition of PDE4B in human U937 cells using [3H] cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502860(CHEMBL4537270)

IC50: 4.25E+3nMAssay Description:Inhibition of PDE4B in human U937 cells using [3H] cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502852(CHEMBL4464755)

IC50: 5.78E+3nMAssay Description:Inhibition of PDE4D in human U937 cells using [3H]cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502866(CHEMBL4472790)

IC50: 6.23E+3nMAssay Description:Inhibition of PDE4B in human U937 cells using [3H] cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502864(CHEMBL4571089)

IC50: 6.36E+3nMAssay Description:Inhibition of PDE4B in human PBMC assessed as inhibition in LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation for ...More data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502858(CHEMBL4451855)

IC50: 6.66E+3nMAssay Description:Inhibition of PDE4D in human U937 cells using [3H]cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502854(CHEMBL4574643)

IC50: 7.53E+3nMAssay Description:Inhibition of PDE4B in human PBMC assessed as inhibition in LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation for ...More data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502863(CHEMBL4542316)

IC50: 8.32E+3nMAssay Description:Inhibition of PDE4B in human U937 cells using [3H] cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502857(CHEMBL4529642)

IC50: 8.38E+3nMAssay Description:Inhibition of PDE4B in human U937 cells using [3H] cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502856(CHEMBL4571951)

IC50: 8.77E+3nMAssay Description:Inhibition of PDE4B in human U937 cells using [3H] cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502853(CHEMBL4578186)

IC50: 1.01E+4nMAssay Description:Inhibition of PDE4D in human U937 cells using [3H]cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502859(CHEMBL4585341)

IC50: 1.04E+4nMAssay Description:Inhibition of PDE4B in human PBMC assessed as inhibition in LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation for ...More data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502859(CHEMBL4585341)

IC50: 1.12E+4nMAssay Description:Inhibition of PDE4D in human U937 cells using [3H]cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502854(CHEMBL4574643)

IC50: 1.13E+4nMAssay Description:Inhibition of PDE4D in human U937 cells using [3H]cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)

IC50: 1.14E+4nMAssay Description:Inhibition of PDE4B in human PBMC assessed as inhibition in LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation for ...More data for this Ligand-Target Pair

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3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502853(CHEMBL4578186)

IC50: 1.26E+4nMAssay Description:Inhibition of PDE4B in human PBMC assessed as inhibition in LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation for ...More data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502864(CHEMBL4571089)

IC50: 1.38E+4nMAssay Description:Inhibition of PDE4D in human U937 cells using [3H]cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502865(CHEMBL4470613)

IC50: 1.58E+4nMAssay Description:Inhibition of PDE4D in human U937 cells using [3H]cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502855(CHEMBL4461167)

IC50: 1.65E+4nMAssay Description:Inhibition of PDE4B in human U937 cells using [3H] cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502867(CHEMBL4447428)

IC50: 1.79E+4nMAssay Description:Inhibition of PDE4B in human PBMC assessed as inhibition in LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation for ...More data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502861(CHEMBL4567007)

IC50: 1.84E+4nMAssay Description:Inhibition of PDE4B in human U937 cells using [3H] cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502860(CHEMBL4537270)

IC50: 1.93E+4nMAssay Description:Inhibition of PDE4B in human PBMC assessed as inhibition in LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation for ...More data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502862(CHEMBL4537714)

IC50: 2.05E+4nMAssay Description:Inhibition of PDE4B in human U937 cells using [3H] cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502865(CHEMBL4470613)

IC50: 2.09E+4nMAssay Description:Inhibition of PDE4B in human PBMC assessed as inhibition in LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation for ...More data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502867(CHEMBL4447428)

IC50: 2.62E+4nMAssay Description:Inhibition of PDE4D in human U937 cells using [3H]cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502866(CHEMBL4472790)

IC50: 2.94E+4nMAssay Description:Inhibition of PDE4B in human PBMC assessed as inhibition in LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation for ...More data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502860(CHEMBL4537270)

IC50: 2.97E+4nMAssay Description:Inhibition of PDE4D in human U937 cells using [3H]cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502866(CHEMBL4472790)

IC50: 3.28E+4nMAssay Description:Inhibition of PDE4D in human U937 cells using [3H]cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502857(CHEMBL4529642)

IC50: 3.65E+4nMAssay Description:Inhibition of PDE4B in human PBMC assessed as inhibition in LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation for ...More data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502856(CHEMBL4571951)

IC50: 3.67E+4nMAssay Description:Inhibition of PDE4D in human U937 cells using [3H]cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502863(CHEMBL4542316)

IC50: 3.74E+4nMAssay Description:Inhibition of PDE4D in human U937 cells using [3H]cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502857(CHEMBL4529642)

IC50: 3.86E+4nMAssay Description:Inhibition of PDE4D in human U937 cells using [3H]cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair

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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502863(CHEMBL4542316)

IC50: 4.16E+4nMAssay Description:Inhibition of PDE4B in human PBMC assessed as inhibition in LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation for ...More data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502856(CHEMBL4571951)

IC50: 4.32E+4nMAssay Description:Inhibition of PDE4B in human PBMC assessed as inhibition in LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation for ...More data for this Ligand-Target Pair

PDB Reactome pathway
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High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502852(CHEMBL4464755)

IC50: >2.00E+5nMAssay Description:Inhibition of PDE7A (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502852(CHEMBL4464755)

IC50: >2.00E+5nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502858(CHEMBL4451855)

IC50: >2.00E+5nMAssay Description:Inhibition of PDE6C (unknown origin)More data for this Ligand-Target Pair

UniProtKB/SwissProt
antibodypedia GoogleScholar

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High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502858(CHEMBL4451855)

IC50: >2.00E+5nMAssay Description:Inhibition of PDE7A (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
South China Agricultural University

Curated by ChEMBL

BDBM50502852(CHEMBL4464755)

IC50: >2.00E+5nMAssay Description:Inhibition of PDE8A1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Displayed 1 to 50 (of 65 total ) | Next | Last >>

Filter my 65 hits

Targets 12▿
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B 31
- cAMP-specific 3',5'-cyclic phosphodiesterase 4D 14
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 2
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 2
- cGMP-specific 3',5'-cyclic phosphodiesterase 2
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B 2
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 2
- Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 2
- cGMP-dependent 3',5'-cyclic phosphodiesterase 2
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 2
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 2
Publications 1▿
- Bioorg Med Chem Lett 29: (2019) 65
Institutions 1▿
- South China Agricultural University 65
Affinity: 2.2E+2 to 2.0E+5 nM▿
- IC50 65
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1