Compile Data Set for Download or QSAR
Report error Found 354 Enz. Inhib. hit(s) with all data for entry = 50006744
LigandChemical structure of BindingDB Monomer ID 50392788BDBM50392788(CHEMBL457614)
Affinity DataKd:  0.204nMAssay Description:Binding affinity to wild type human biotinylated and N-terminal DYKDDDDK-tagged TrkA kinase domain (436 to 790 residues) expressed in Sf21 cells asse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50392788BDBM50392788(CHEMBL457614)
Affinity DataKi:  0.360nMAssay Description:Inhibition of human active TRKA assessed as decrease in substrate phosphorylation incubated for 2 hrs using CSKtide as substrate in presence of ATP m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50502883BDBM50502883(CHEMBL4444901)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50392788BDBM50392788(CHEMBL457614)
Affinity DataKi:  3.70nMAssay Description:Inhibition of human inactive TRKA assessed as decrease in substrate phosphorylation incubated for 2 hrs using CSKtide as substrate in presence of ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50502881BDBM50502881(CHEMBL4577285)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502933BDBM50502933(CHEMBL4573890)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502970BDBM50502970(CHEMBL4524989)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502956BDBM50502956(CHEMBL4461600)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502967BDBM50502967(CHEMBL4466061)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502896BDBM50502896(CHEMBL4458913)
Affinity DataIC50: 10nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50502896BDBM50502896(CHEMBL4458913)
Affinity DataKd:  11.4nMAssay Description:Binding affinity to wild type human biotinylated and N-terminal DYKDDDDK-tagged TrkA kinase domain (436 to 790 residues) expressed in Sf21 cells asse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50502908BDBM50502908(CHEMBL4468419)
Affinity DataIC50: 12nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502919BDBM50502919(CHEMBL4553953)
Affinity DataIC50: 12nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502978BDBM50502978(CHEMBL4515321)
Affinity DataIC50: 19nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502897BDBM50502897(CHEMBL4545062)
Affinity DataIC50: 19nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502871BDBM50502871(CHEMBL4448181)
Affinity DataIC50: 20nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502965BDBM50502965(CHEMBL4467890)
Affinity DataIC50: 21nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502896BDBM50502896(CHEMBL4458913)
Affinity DataKi:  21nMAssay Description:Inhibition of human inactive TRKA assessed as decrease in substrate phosphorylation incubated for 2 hrs using CSKtide as substrate in presence of ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50502922BDBM50502922(CHEMBL4557960)
Affinity DataIC50: 24nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502874BDBM50502874(CHEMBL4527557)
Affinity DataIC50: 24nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502951BDBM50502951(CHEMBL4466950)
Affinity DataIC50: 25nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502961BDBM50502961(CHEMBL4592814)
Affinity DataIC50: 25nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502955BDBM50502955(CHEMBL4545212)
Affinity DataIC50: 25nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502952BDBM50502952(CHEMBL4590914)
Affinity DataIC50: 26nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502943BDBM50502943(CHEMBL4456764)
Affinity DataIC50: 28nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502937BDBM50502937(CHEMBL4563845)
Affinity DataIC50: 31nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502938BDBM50502938(CHEMBL4443873)
Affinity DataIC50: 32nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502914BDBM50502914(CHEMBL4439123)
Affinity DataIC50: 33nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502896BDBM50502896(CHEMBL4458913)
Affinity DataIC50: 34nMAssay Description:Inhibition of TrkA in rat PC12 cells assessed as reduction in beta-NGF-induced neurite outgrowth preincubated for 30 mins followed by beta-NGF stimul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50502894BDBM50502894(CHEMBL4458775)
Affinity DataIC50: 38nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502931BDBM50502931(CHEMBL4450785)
Affinity DataIC50: 41nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502945BDBM50502945(CHEMBL4579043)
Affinity DataIC50: 41nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502872BDBM50502872(CHEMBL4533532)
Affinity DataIC50: 42nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502976BDBM50502976(CHEMBL4461532)
Affinity DataIC50: 45nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502915BDBM50502915(CHEMBL4470140)
Affinity DataIC50: 47nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502949BDBM50502949(CHEMBL4449741)
Affinity DataIC50: 51nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502892BDBM50502892(CHEMBL4536149)
Affinity DataIC50: 55nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502889BDBM50502889(CHEMBL4561854)
Affinity DataIC50: 58nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502888BDBM50502888(CHEMBL4451361)
Affinity DataIC50: 59nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502969BDBM50502969(CHEMBL4466913)
Affinity DataIC50: 60nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502977BDBM50502977(CHEMBL4562063)
Affinity DataIC50: 62nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Zoetis

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502919BDBM50502919(CHEMBL4553953)
Affinity DataIC50: 64nMAssay Description:Inhibition of human full length TRKB expressed in CHO cells assessed as decrease in NGF-induced Ca2+ flux by Calcium 4 dye-based FLIPR TETRA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502946BDBM50502946(CHEMBL4552667)
Affinity DataIC50: 65nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502972BDBM50502972(CHEMBL4452210)
Affinity DataIC50: 66nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502896BDBM50502896(CHEMBL4458913)
Affinity DataKi:  67nMAssay Description:Inhibition of human active TRKA assessed as decrease in substrate phosphorylation incubated for 2 hrs using CSKtide as substrate in presence of ATP m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50502918BDBM50502918(CHEMBL4546610)
Affinity DataIC50: 68nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502966BDBM50502966(CHEMBL4453384)
Affinity DataIC50: 68nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502984BDBM50502984(CHEMBL4584518)
Affinity DataIC50: 69nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502981BDBM50502981(CHEMBL4463148)
Affinity DataIC50: 79nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502876BDBM50502876(CHEMBL4547987)
Affinity DataIC50: 83nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
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