Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50011749
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50069959BDBM50069959(Sodium; 6-fluoro-2-(2'-fluoro-biphenyl-4-yl)-3-met...)
Affinity DataEC50:  55nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16111BDBM16111(2-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}c...)
Affinity DataEC50:  2.75E+3nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16111BDBM16111(2-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}c...)
Affinity DataEC50:  2.80E+3nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50018011BDBM50018011(CHEBI:68540 | HMR-1726 | Aubagio | TERIFLUNOMIDE)
Affinity DataEC50:  8.90E+3nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50018011BDBM50018011(CHEBI:68540 | HMR-1726 | Aubagio | TERIFLUNOMIDE)
Affinity DataEC50:  8.91E+3nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550724BDBM50550724(CHEMBL4750208)
Affinity DataEC50:  2.69E+4nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550724BDBM50550724(CHEMBL4750208)
Affinity DataEC50:  2.70E+4nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550723BDBM50550723(CHEMBL4740037)
Affinity DataEC50:  4.40E+4nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550723BDBM50550723(CHEMBL4740037)
Affinity DataEC50:  4.47E+4nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550728BDBM50550728(CHEMBL4748412)
Affinity DataEC50:  5.25E+4nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550727BDBM50550727(CHEMBL3128253)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550737BDBM50550737(CHEMBL4743368)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550736BDBM50550736(CHEMBL4741980)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550735BDBM50550735(CHEMBL4748394)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550726BDBM50550726(CHEMBL3128254)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550734BDBM50550734(CHEMBL4789182)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550725BDBM50550725(CHEMBL4790954)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550733BDBM50550733(CHEMBL4795021)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550732BDBM50550732(CHEMBL4755999)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550731BDBM50550731(CHEMBL4745158)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550730BDBM50550730(CHEMBL4777624)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50550729BDBM50550729(CHEMBL4753543)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed