Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50007956
TargetCarbonic anhydrase 2(Bovine)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514428BDBM50514428(CHEMBL4450233)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514417BDBM50514417(CHEMBL4540374)
Affinity DataKd:  10nMAssay Description:Binding affinity to human COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetLuciferin 4-monooxygenase(Common eastern firefly)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514408BDBM50514408(CHEMBL4435351)
Affinity DataIC50: 10nMAssay Description:Inhibition of Photinus pyralis luciferase using ATP and D-luciferin in presence of Coenzyme A and DL-cysteine by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50462575BDBM50462575(CHEMBL4238121)
Affinity DataKi:  29nMAssay Description:Inhibition human FA10a using Boc-LeuGly-Arg-AMC fluorogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Bovine)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50236140BDBM50236140(4-ethynyl benzene sulfonamide | 4-ethynylbenzenesu...)
Affinity DataKd:  37nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProthrombin(Human)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514426BDBM50514426(CHEMBL4574713)
Affinity DataKi:  50nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514416BDBM50514416(CHEMBL4466030)
Affinity DataIC50: 50nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514415BDBM50514415(CHEMBL4527561)
Affinity DataIC50: 56nMAssay Description:Inhibition of human recombinant IDE pre-incubated for 10 mins before Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp substrate addition and measured after 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514406BDBM50514406(CHEMBL4444391)
Affinity DataIC50: 60nMAssay Description:Inhibition of COX2 human HCA7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11639BDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514416BDBM50514416(CHEMBL4466030)
Affinity DataIC50: 80nMAssay Description:Inhibition of COX2 human HCA7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514406BDBM50514406(CHEMBL4444391)
Affinity DataIC50: 90nMAssay Description:Inhibition of human COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11639BDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 90nMAssay Description:Inhibition of COX2 human HCA7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50514409BDBM50514409(CHEMBL4549938)
Affinity DataKi:  600nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBifunctional ligase/repressor BirA(Staphylococcus aureus)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514425BDBM50514425(CHEMBL4462026)
Affinity DataKi:  1.40E+3nMAssay Description:Binding affinity to Staphylococcus aureus biotin protein ligaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50514407BDBM50514407(CHEMBL4483038)
Affinity DataIC50: 1.40E+3nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50514413BDBM50514413(CHEMBL4555061)
Affinity DataIC50: 2.90E+3nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNAD kinase 1(Listeria monocytogenes serovar 1/2a (strain ATCC B...)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514423BDBM50514423(CHEMBL4552749)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibition of Listeria monocytogenes NAD kinase assessed as suppression of reduced NADP formation by yeast glucose-6-phosphate dehydrogenase coupled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50514414BDBM50514414(CHEMBL4439829)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of STAT5b in mouse BaF3/FLT3-ITD cells assessed as reduction in cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50514414BDBM50514414(CHEMBL4439829)
Affinity DataIC50: 3.70E+4nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetEndothiapepsin(Chestnut blight fungus)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514427BDBM50514427(CHEMBL4452904)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of Cryphonectria parasitica Endothiapepsin using Abz-Thr-Ile-Nle-p-nitro-Phe-Gln-Arg-NH2 substrate by fluorescence screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50514413BDBM50514413(CHEMBL4555061)
Affinity DataIC50: 7.60E+4nMAssay Description:Inhibition of STAT5b in mouse BaF3/FLT3-ITD cells assessed as reduction in cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50514407BDBM50514407(CHEMBL4483038)
Affinity DataIC50: 1.53E+5nMAssay Description:Inhibition of STAT5b in mouse BaF3/FLT3-ITD cells assessed as reduction in cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 23234BDBM23234(4-amino-1,2,5-oxadiazole-3-carboxylic acid | 1,2,5...)
Affinity DataKi:  4.20E+5nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50232690BDBM50232690(4-Aminomethyl-Benzamidine | CHEMBL187301)
Affinity DataKi:  6.80E+5nMAssay Description:Inhibition human FA10a using Boc-LeuGly-Arg-AMC fluorogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50514424BDBM50514424(CHEMBL4452459)
Affinity DataKi: >5.00E+6nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50514411BDBM50514411(CHEMBL4574617)
Affinity DataKi: >5.00E+6nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50514421BDBM50514421(CHEMBL4438181)
Affinity DataKi: >5.00E+6nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50514412BDBM50514412(CHEMBL4462216)
Affinity DataKi: >5.00E+6nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50514422BDBM50514422(CHEMBL4466928)
Affinity DataKi: >5.00E+6nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50514419BDBM50514419(CHEMBL4454339)
Affinity DataKi: >5.00E+6nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50514410BDBM50514410(CHEMBL4566571)
Affinity DataKi: >5.00E+6nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50514420BDBM50514420(CHEMBL4459159)
Affinity DataKi: >5.00E+6nMAssay Description:Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514418BDBM50514418(CHEMBL4572188)
Affinity DataKi:  5.50E+6nMAssay Description:Inhibition human FA10a using Boc-LeuGly-Arg-AMC fluorogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed