Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) with all data for entry = 50022627
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 46nMAssay Description:Inhibition of JAK2 in human A-431 cells assessed as reduction in IL-6-induced STAT3 phosphorylation preincubated for 1 hr followed by IL-6-stimulatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM202553((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...)
Affinity DataIC50: 127nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of ATP by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM202553((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...)
Affinity DataIC50: 930nMAssay Description:Inhibition of JAK1/JAK2 in human A-431 cells assessed as reduction in IL-6-induced STAT3 phosphorylation at 1 uM preincubated for 1 hr followed by IL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed