Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50011124
TargetHistone-lysine N-methyltransferase SETD7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50075073(CHEMBL3414622)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human SET7 expressed in Escherichia coli using [3H] SAM as substrate by scintillation counter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase SETD7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM23411(5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of human SET7 overexpressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins followed by addition of SAM as substrate and bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM23411(5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Affinity DataIC50: 2.65E+3nMAssay Description:Inhibition of NSD2 (unknown origin) preincubated for 15 mins followed by addition of [3H]-SAM as substrate and peptide solution after 240 mins cold S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM23411(5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Affinity DataIC50: 2.92E+3nMAssay Description:Inhibition of MLL1 (unknown origin) preincubated for 15 mins followed by addition of substrate measured after 1 hr by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETD7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM26658(2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-...)
Affinity DataIC50: 6.02E+3nMAssay Description:Inhibition of human SET7 overexpressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins followed by addition of SAM as substrate and bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETD7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50: 6.08E+3nMAssay Description:Inhibition of human SET7 overexpressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins followed by addition of SAM as substrate and bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM23411(5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Affinity DataIC50: 8.77E+3nMAssay Description:Inhibition of Ezh1 (unknown origin) preincubated for 15 mins followed by addition of substrate measured after 1 hr by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM23411(5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of SMYD3 (unknown origin) preincubated for 15 mins followed by addition of [3H]-SAM as substrate and peptide solution after 240 mins cold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETD7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50033731(5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...)
Affinity DataIC50: 2.16E+4nMAssay Description:Inhibition of human SET7 overexpressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins followed by addition of SAM as substrate and bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETD7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM7462(cid_5280863 | CHEMBL150 | 3,5,7-trihydroxy-2-(4-hy...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human SET7 overexpressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins followed by addition of SAM as substrate and bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETD7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50049391(norizalpinin | 3,5,7-trihydroxy-2-phenyl-4H-benzop...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human SET7 overexpressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins followed by addition of SAM as substrate and bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETD7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50084978(Kaempferide | Kaempferol 4'-methyl ether | CHEMBL4...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human SET7 overexpressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins followed by addition of SAM as substrate and bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETD7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50325671(CHEMBL8996 | eriodicryol | (S)-2-(3,4-dihydroxyphe...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human SET7 overexpressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins followed by addition of SAM as substrate and bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed