Compile Data Set for Download or QSAR
Report error Found 80 Enz. Inhib. hit(s) with all data for entry = 50012720
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50415001BDBM50415001(GSK-256066 | CHEMBL570015 | GSK-256066 (3))
Affinity DataIC50: 0.00300nMAssay Description:Inhibition of human PDE4 expressed in Saccharomyces cerevisiae preincubated for 30 mins followed by cAMP substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559714BDBM50559714(CHEMBL4794267)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of recombinant human PDE4B2 preincubated for 30 mins followed by [3H]cyclic AMP addition and measured after 20 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559706BDBM50559706(CHEMBL4744560)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of recombinant human PDE4B2 using cAMP as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 14775BDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of human PDE4D by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50495704BDBM50495704(Chf-6001 | Chf6001 | J3.309.618F)
Affinity DataIC50: 0.0260nMAssay Description:Inhibition of PDE4 in human U937 cell lysate using cAMP as substrate by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199701BDBM50199701(CHEMBL3968147)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of PDE4 (unknown origin) expressed in Saccharomyces cerevisiae using [3H] cAMP as substrate incubated for 1 hr by scintillation proximity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 14775BDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 0.0410nMAssay Description:Inhibition of human PDE4B by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559711BDBM50559711(CHEMBL4800045)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE4 (unknown origin) expressed in Saccharomyces cerevisiae using [3H] cAMP as substrate incubated for 1 hr by scintillation proximity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559713BDBM50559713(CHEMBL4759356)
Affinity DataIC50: 0.126nMAssay Description:Inhibition of recombinant human PDE4B2 preincubated for 30 mins followed by [3H]cyclic AMP addition and measured after 20 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559690BDBM50559690(CHEMBL4799033)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559694BDBM50559694(CHEMBL4752721)
Affinity DataIC50: 0.355nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50017340BDBM50017340(CHEMBL3113734)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of PDE4A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50017340BDBM50017340(CHEMBL3113734)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of PDE4B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50017340BDBM50017340(CHEMBL3113734)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559710BDBM50559710(CHEMBL4793329)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human U937 cell derived PDE4 preincubated for 15 mins followed by [3H]AMP and cAMP addition and measured after 20 mins by liquid scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50347348BDBM50347348(CHEMBL1801160)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 14774BDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.680nMAssay Description:Inhibition of human PDE4D by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 14774BDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.840nMAssay Description:Inhibition of human PDE4B by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559712BDBM50559712(CHEMBL4758412)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant human PDE4B expressed in Sf9 cells by IMAP phosphodiesterase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50495743BDBM50495743(CHEMBL3113736)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559695BDBM50559695(CHEMBL4759825)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559691BDBM50559691(CHEMBL4794439)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559709BDBM50559709(Lotamilast | E-6005 | E6005 | RVT-501)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human U-937 cell derived PDE4 using [3H]-cAMP or [3H]-cGMP as substrate incubated for 60 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559699BDBM50559699(CHEMBL4759270)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST tagged full length human PDE4B2 expressed in baculovirus infected Sf9 cell expression system using cAMP as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559700BDBM50559700(CHEMBL4784887)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST tagged full length human PDE4B2 expressed in baculovirus infected Sf9 cell expression system using cAMP as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559701BDBM50559701(CHEMBL4787980)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST tagged full length human PDE4B2 expressed in baculovirus infected Sf9 cell expression system using cAMP as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559702BDBM50559702(CHEMBL4750999)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST tagged full length human PDE4B2 expressed in baculovirus infected Sf9 cell expression system using cAMP as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559703BDBM50559703(CHEMBL4757093)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST tagged full length human PDE4B2 expressed in baculovirus infected Sf9 cell expression system using cAMP as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559704BDBM50559704(CHEMBL4752341)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST tagged full length human PDE4B2 expressed in baculovirus infected Sf9 cell expression system using cAMP as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559699BDBM50559699(CHEMBL4759270)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST tagged full length human PDE4C1 expressed in baculovirus infected Sf9 cell expression system using cAMP as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559703BDBM50559703(CHEMBL4757093)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST tagged full length human PDE4C1 expressed in baculovirus infected Sf9 cell expression system using cAMP as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559701BDBM50559701(CHEMBL4787980)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST tagged full length human PDE4C1 expressed in baculovirus infected Sf9 cell expression system using cAMP as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559702BDBM50559702(CHEMBL4750999)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST tagged full length human PDE4C1 expressed in baculovirus infected Sf9 cell expression system using cAMP as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559704BDBM50559704(CHEMBL4752341)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST tagged full length human PDE4C1 expressed in baculovirus infected Sf9 cell expression system using cAMP as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559700BDBM50559700(CHEMBL4784887)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST tagged full length human PDE4C1 expressed in baculovirus infected Sf9 cell expression system using cAMP as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559692BDBM50559692(CHEMBL4568146)
Affinity DataIC50: 3nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559696BDBM50559696(Revamilast)
Affinity DataIC50: 3nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50473353BDBM50473353(CHEMBL421528)
Affinity DataIC50: 4nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559723BDBM50559723(CHEMBL4746212)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human PDE4B2 using cAMP as substrate preincubated for 5 mins followed by substrate addition and measured after 60 mins by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50317603BDBM50317603(8-(cyclopentyloxy)-4-(3,5-dichloropyridin-4-ylamin...)
Affinity DataIC50: 5nMAssay Description:Inhibition of NH2-terminal His6-tagged PDE4B catalytic domain (unknown origin) using Cyclic AMP as substrate incubated for 10 mins followed by substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559721BDBM50559721(CHEMBL4745497)
Affinity DataIC50: 5nMAssay Description:Inhibition of human PDE4B2 expressed in HEK293 cells using cAMP as substrate incubated for 45 to 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559708BDBM50559708(CHEMBL4789722)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of full length human PDE4B2 expressed in baculovirus infected Sf9 cell expression system preincubated for 10 mins followed by cAMP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559693BDBM50559693(CHEMBL4781411)
Affinity DataIC50: 7nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559718BDBM50559718(Pumafentrine | Pumafentrin | BY-343 | BY343 | BYK-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human neutrophil derived PDE4More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559723BDBM50559723(CHEMBL4746212)
Affinity DataEC50:  8nMAssay Description:Agonist activity at recombinant human beta2 adrenergic receptor expressed in CHO cells in presence of [3H](-)CGP12177More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50457395BDBM50457395(CHEMBL4209111 | US11401286, Example 220)
Affinity DataIC50: 8nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559707BDBM50559707(CHEMBL3113735)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of cytosolic PDE4 in human PMNL using [3H]cAMP as substrate by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559716BDBM50559716(CHEMBL4751199)
Affinity DataIC50: 11nMAssay Description:Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli BL21 cells using 3H-cGMP or 3H-cAMP as substrate by li...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50273512BDBM50273512(1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)ph...)
Affinity DataIC50: 12nMAssay Description:Inhibition of PDE4D2 (1 to 507 residues) (unknown origin) by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Sichuan Academy of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559719BDBM50559719(CHEMBL4750033)
Affinity DataIC50: 12nMAssay Description:Inhibition of human PDE4 using [3H]cAMP as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
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