Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50010989
TargetAcyl-protein thioesterase 1(Rat)
Peking University First Hospital

Curated by ChEMBL
LigandPNGBDBM50543969(CHEMBL4640030)
Affinity DataKi:  23nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged FAP (unknown origin) (38 to 760 residues) expressed in HEK293 cells using AMCC as substrate by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1(Rat)
Peking University First Hospital

Curated by ChEMBL
LigandPNGBDBM50009366(CHEMBL3233842 | US9346814, Cmpd No 1, Example 1 | ...)
Affinity DataIC50: 42nMAssay Description:Inhibition of FAP in human U87MG cells using Suc-Gly-Pro-AMC as substrate measured upto 60 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1(Rat)
Peking University First Hospital

Curated by ChEMBL
LigandPNGBDBM50009366(CHEMBL3233842 | US9346814, Cmpd No 1, Example 1 | ...)
Affinity DataIC50: 55nMAssay Description:Inhibition of FAP in human U87MG cells using Suc-Gly-Pro-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1(Rat)
Peking University First Hospital

Curated by ChEMBL
LigandPNGBDBM50050513(Ketopyrrolidine derivative | (R)-1-((S)-2-amino-3-...)
Affinity DataIC50: 224nMAssay Description:Inhibition of FAP in human U87MG cells using Suc-Gly-Pro-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1(Rat)
Peking University First Hospital

Curated by ChEMBL
LigandPNGBDBM50543969(CHEMBL4640030)
Affinity DataIC50: 663nMAssay Description:Inhibition of FAP in human U87MG cells using Suc-Gly-Pro-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1(Rat)
Peking University First Hospital

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of FAP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1(Rat)
Peking University First Hospital

Curated by ChEMBL
LigandPNGBDBM50543970(CHEMBL4647532)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of FAP in human U87MG cells using Suc-Gly-Pro-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1(Rat)
Peking University First Hospital

Curated by ChEMBL
LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataIC50: 7.98E+4nMAssay Description:Inhibition of FAP in human U87MG cells using Suc-Gly-Pro-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1(Rat)
Peking University First Hospital

Curated by ChEMBL
LigandPNGBDBM11162(Triazolopiperazine Analogue 1 | (3R)-3-amino-1-[3-...)
Affinity DataIC50: 8.53E+4nMAssay Description:Inhibition of FAP in human U87MG cells using Suc-Gly-Pro-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1(Rat)
Peking University First Hospital

Curated by ChEMBL
LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataIC50: 1.47E+6nMAssay Description:Inhibition of FAP in human U87MG cells using Suc-Gly-Pro-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1(Rat)
Peking University First Hospital

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 1.72E+6nMAssay Description:Inhibition of FAP in human U87MG cells using Suc-Gly-Pro-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed