Compile Data Set for Download or QSAR
Report error Found 45 Enz. Inhib. hit(s) with all data for entry = 50018350
TargetHistone deacetylase 3(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50481803(CHEMBL5269123)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant HDAC3 incubated for 20 mins by HDAC Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50481803(CHEMBL5269123)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human recombinant GST-tagged HDAC1 incubated for 20 mins by HDAC Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM172038(US10647700, Compound EPZ6438 | BDBM190183 | US1015...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of PRC2 catalytic core EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50481803(CHEMBL5269123)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human recombinant GST-tagged HDAC2 incubated for 20 mins by HDAC Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataKd:  3.5nMAssay Description:Binding affinity to BRD4 BD2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataKd:  4.70nMAssay Description:Binding affinity to BRD2 BD2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataKd:  7.60nMAssay Description:Binding affinity to BRD3 BD2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataKd:  7.60nMAssay Description:Binding affinity to BRD4 BD2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataKd:  8.30nMAssay Description:Binding affinity to BRD3 BD1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataKd:  9.60nMAssay Description:Binding affinity to BRD4 BD1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50481803(CHEMBL5269123)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant His-tagged HDAC10 incubated for 20 mins by HDAC Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50536555(CHEMBL4532174)
Affinity DataIC50: 12nMAssay Description:Inhibition of EZH2 methyltransferase activity (unknown origin) assessed `transfer of [3H]methyl group from SAM to substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataKd:  14nMAssay Description:Binding affinity to BRD4 BD1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50512415(CHEMBL4226052)
Affinity DataKd:  28nMAssay Description:Binding affinity to BRD4 BD1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50512415(CHEMBL4226052)
Affinity DataKd:  28nMAssay Description:Binding affinity to BRD4 BD2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataIC50: 33nMAssay Description:Inhibition of BRD4-BD2 domain (unknown origin) assessed as inhibition of tetra-acetylated Histone H4 peptide binding to BRD4 by ALPHA-screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataKd:  34nMAssay Description:Binding affinity to BRD2 BD1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50481804(CHEMBL5281933)
Affinity DataKd:  35nMAssay Description:Binding affinity to BRD3 BD1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50481803(CHEMBL5269123)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant GST-tagged HDAC6 incubated for 20 mins by HDAC Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50481804(CHEMBL5281933)
Affinity DataKd:  39nMAssay Description:Binding affinity to BRD3 BD2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50481804(CHEMBL5281933)
Affinity DataKd:  44nMAssay Description:Binding affinity to BRD4 BD2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPolycomb protein EED(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataIC50: 45nMAssay Description:Inhibition of His tagged EED (1 to 441) (unknown origin) using biotin-H3K27me3 peptide as substrate by AlphaScreen competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataKd:  49nMAssay Description:Binding affinity to BRD4 BD1 domain (unknown origin) by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50481803(CHEMBL5269123)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant His-tagged HDAC8 incubated for 20 mins by HDAC Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50481804(CHEMBL5281933)
Affinity DataKd:  75nMAssay Description:Binding affinity to BRD4 BD1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataIC50: 77nMAssay Description:Inhibition of BRD4-BD1 domain (unknown origin) assessed as inhibition of tetra-acetylated Histone H4 peptide binding to BRD4 by ALPHA-screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataKd:  90nMAssay Description:Binding affinity to BRD4 BD2 domain (unknown origin) by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50: 92nMAssay Description:Inhibition of BRD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50: 92nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50: 92nMAssay Description:Inhibition of BRD3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50481804(CHEMBL5281933)
Affinity DataKd:  94nMAssay Description:Binding affinity to BRD2 BD2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50481804(CHEMBL5281933)
Affinity DataKd:  111nMAssay Description:Binding affinity to BRD2 BD1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  115nMAssay Description:Binding affinity to BRD3 BD2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  119nMAssay Description:Binding affinity to BRD3 BD1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  120nMAssay Description:Binding affinity to BRD4 BD2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50562609(CHEMBL4787413)
Affinity DataIC50: 120nMAssay Description:Inhibition of EZH2 methyltransferase activity (unknown origin) assessed `transfer of [3H]methyl group from SAM to substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  228nMAssay Description:Binding affinity to BRD2 BD2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPolycomb protein EED(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50562612(CHEMBL4749741)
Affinity DataIC50: 247nMAssay Description:Inhibition of PRC2 catalytic core EED (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  307nMAssay Description:Binding affinity to BRD2 BD1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetProbable global transcription activator SNF2L2(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM394406(US10308614, Example 7 | 2-(6-amino-5-(piperazin-)
Affinity DataIC50: 370nMAssay Description:Inhibition of SMARCA2 BD (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  382nMAssay Description:Binding affinity to BRD4 BD1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTranscription activator BRG1(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM394406(US10308614, Example 7 | 2-(6-amino-5-(piperazin-)
Affinity DataIC50: 550nMAssay Description:Inhibition of SMARCA4 BD (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTranscription activator BRG1(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50481805(CHEMBL5278697)
Affinity DataIC50: 560nMAssay Description:Inhibition of SMARCA4 BD (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetProbable global transcription activator SNF2L2(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50481805(CHEMBL5278697)
Affinity DataIC50: 770nMAssay Description:Inhibition of SMARCA2 BD (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH1(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50536555(CHEMBL4532174)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of EZH1 methyltransferase activity (unknown origin) assessed `transfer of [3H]methyl group from SAM to substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed