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Found 15 Enz. Inhib. hit(s) with all data for entry = 50013092
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM28583(5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50562651(CHEMBL4788250)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membrane measured after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50019754(IDALOPIRDINE | LU-AE58054)
Affinity DataKi:  6.90nMAssay Description:Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membrane measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50562651(CHEMBL4788250)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membrane measured after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate peincubated for 5 mins followed by substrate addition by DTNB-reagen...More data for this Ligand-Target Pair
TargetCholinesterase(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM11682(2,3-dihydroxybutanedioic acid; 3-[(1S)-1-(dimethyl...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human BuChE using S-butyrylthiocholine as substrate preincubated for 30 mins followed by substrate addition and measured after 25 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCholinesterase(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  85nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate peincubated for 5 mins followed by substrate addition by DTNB-reagent based El...More data for this Ligand-Target Pair
TargetCholinesterase(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50562650(CHEMBL4744490)
Affinity DataIC50:  835nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate peincubated for 5 mins followed by substrate addition by DTNB-reagent based El...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50562650(CHEMBL4744490)
Affinity DataIC50:  927nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate peincubated for 5 mins followed by substrate addition by DTNB-reagent based El...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50019754(IDALOPIRDINE | LU-AE58054)
Affinity DataIC50:  1.00E+3nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in COS-7 cells assessed as inhibition of 5HT-induced cAMP accumulation preincubated for 7 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50562651(CHEMBL4788250)
Affinity DataIC50:  2.00E+3nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in COS-7 cells assessed as inhibition of 5HT-induced cAMP accumulation preincubated for 7 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM11682(2,3-dihydroxybutanedioic acid; 3-[(1S)-1-(dimethyl...)
Affinity DataIC50:  4.15E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine as substrate preincubated for 30 mins followed by substrate addition and measured after 25 mins by D...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCholinesterase(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50344263((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate peincubated for 5 mins followed by substrate addition by DTNB-reagent based El...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50562650(CHEMBL4744490)
Affinity DataIC50:  1.65E+4nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate peincubated for 5 mins followed by substrate addition by DTNB-reagen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Normandie Univ

Curated by ChEMBL
LigandPNGBDBM50562650(CHEMBL4744490)
Affinity DataIC50:  1.76E+4nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate peincubated for 5 mins followed by substrate addition by DTNB-reagen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed