Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50013848
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570254(CHEMBL4865865)
Affinity DataKi:  8.40nMAssay Description:Binding affinity to wild-type androgen receptor in human LNCaP cells assessed as inhibition constant incubated for 24 hrs by Cheng-Prusoff equation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50425732(Xtandi | ENZALUTAMIDE | US10053433, FC 4.129 | US1...)
Affinity DataKi:  17nMAssay Description:Binding affinity to wild-type androgen receptor in human LNCaP cells assessed as inhibition constant incubated for 24 hrs by Cheng-Prusoff equation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570254(CHEMBL4865865)
Affinity DataIC50: 19nMAssay Description:Displacement of [3H]methyltrienolone from wild-type androgen receptor in human LNCaP cells incubated for 24 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM493530(US10981926, Cpd No. 43 | 5-[5-oxo-8-[6-(4-piperidy...)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570257(CHEMBL4862827)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50425732(Xtandi | ENZALUTAMIDE | US10053433, FC 4.129 | US1...)
Affinity DataIC50: 38nMAssay Description:Displacement of [3H]methyltrienolone from wild-type androgen receptor in human LNCaP cells incubated for 24 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570257(CHEMBL4862827)
Affinity DataEC50:  45nMAssay Description:Agonist activity at VP16-AR F877L mutant (unknown origin) transfected in human HepG2 cells cotransfected with ARE-LUC incubated for 48 hrs by steady-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570263(CHEMBL4849570)
Affinity DataIC50: 47nMAssay Description:Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570263(CHEMBL4849570)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM493530(US10981926, Cpd No. 43 | 5-[5-oxo-8-[6-(4-piperidy...)
Affinity DataIC50: 54nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50425732(Xtandi | ENZALUTAMIDE | US10053433, FC 4.129 | US1...)
Affinity DataEC50:  62nMAssay Description:Agonist activity at VP16-AR F877L mutant (unknown origin) transfected in human HepG2 cells cotransfected with ARE-LUC incubated for 48 hrs by steady-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570257(CHEMBL4862827)
Affinity DataIC50: 76nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570262(CHEMBL4879319)
Affinity DataIC50: 81nMAssay Description:Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570258(CHEMBL4859502)
Affinity DataIC50: 85nMAssay Description:Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570254(CHEMBL4865865)
Affinity DataIC50: 98nMAssay Description:Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570256(CHEMBL4860547)
Affinity DataIC50: 102nMAssay Description:Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570258(CHEMBL4859502)
Affinity DataIC50: 115nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50425732(Xtandi | ENZALUTAMIDE | US10053433, FC 4.129 | US1...)
Affinity DataIC50: 117nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570262(CHEMBL4879319)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570254(CHEMBL4865865)
Affinity DataIC50: 127nMAssay Description:Antagonist activity at VP16-AR wild-type (unknown origin) transfected in human HepG2 cells cotransfected with ARE-LUC incubated for 48 hrs in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570259(CHEMBL4876579)
Affinity DataIC50: 145nMAssay Description:Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570256(CHEMBL4860547)
Affinity DataIC50: 162nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570265(CHEMBL4861595)
Affinity DataIC50: 182nMAssay Description:Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570254(CHEMBL4865865)
Affinity DataIC50: 191nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570265(CHEMBL4861595)
Affinity DataIC50: 204nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570264(CHEMBL4853754)
Affinity DataIC50: 204nMAssay Description:Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570255(CHEMBL4869652)
Affinity DataIC50: 214nMAssay Description:Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570259(CHEMBL4876579)
Affinity DataIC50: 240nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570255(CHEMBL4869652)
Affinity DataIC50: 302nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570261(CHEMBL4868340)
Affinity DataIC50: 309nMAssay Description:Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570264(CHEMBL4853754)
Affinity DataIC50: 355nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570260(CHEMBL4850003)
Affinity DataIC50: 417nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570260(CHEMBL4850003)
Affinity DataIC50: 427nMAssay Description:Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570261(CHEMBL4868340)
Affinity DataIC50: 501nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570255(CHEMBL4869652)
Affinity DataEC50:  649nMAssay Description:Agonist activity at VP16-AR F877L mutant (unknown origin) transfected in human HepG2 cells cotransfected with ARE-LUC incubated for 48 hrs by steady-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570256(CHEMBL4860547)
Affinity DataEC50:  838nMAssay Description:Agonist activity at VP16-AR F877L mutant (unknown origin) transfected in human HepG2 cells cotransfected with ARE-LUC incubated for 48 hrs by steady-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570266(CHEMBL4850855)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570266(CHEMBL4850855)
Affinity DataIC50: 2.24E+3nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570254(CHEMBL4865865)
Affinity DataKi:  9.90E+3nMAssay Description:Binding affinity to glucocorticoid receptor in human IM-9 cells assessed as inhibition constant incubated for 6 hrs by Cheng-Prusoff equation analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50425732(Xtandi | ENZALUTAMIDE | US10053433, FC 4.129 | US1...)
Affinity DataKi:  1.40E+4nMAssay Description:Binding affinity to glucocorticoid receptor in human IM-9 cells assessed as inhibition constant incubated for 6 hrs by Cheng-Prusoff equation analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50570254(CHEMBL4865865)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]dexamethasone from glucocorticoid receptor in human IM-9 cells incubated for 6 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50425732(Xtandi | ENZALUTAMIDE | US10053433, FC 4.129 | US1...)
Affinity DataIC50: 2.90E+4nMAssay Description:Displacement of [3H]dexamethasone from glucocorticoid receptor in human IM-9 cells incubated for 6 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed