Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50015597
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50587727(CHEMBL5204926)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of N-terminal 6His-tagged full-length H2N-VE(pY)LDLDLD(PEG8)RVD(pY)VVVDQQ-amide-activated SHP2 (247 to 529 residues) (unknown origin) expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50546219(CHEMBL4752026 | US11596633, Compound B | US1170239...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of N-terminal 6His-tagged full-length H2N-VE(pY)LDLDLD(PEG8)RVD(pY)VVVDQQ-amide-activated SHP2 (247 to 529 residues) (unknown origin) expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50546219(CHEMBL4752026 | US11596633, Compound B | US1170239...)
Affinity DataIC50: 7nMAssay Description:Inhibition of SHP2 in mouse EMT6 cells harboring SOS1 mutationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM38019(US10093646, Compound 1 | US10301278, Example 00003...)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human SHP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50587735(CHEMBL5182949)
Affinity DataIC50: 71nMAssay Description:Inhibition of N-terminal hexaHis-tagged catalytic domain of human SHP2 (248 to 527 residues) expressed as Escherichia coli Rosetta (DE3) using DiFMUP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50587733(CHEMBL5208593)
Affinity DataIC50: 700nMAssay Description:Inhibition of human SHP2 catalytic domain expressed in Escherichia coli using p-nitrophenyl phosphate as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50587732(CHEMBL5209393)
Affinity DataIC50: 800nMAssay Description:Inhibition of human SHP2 catalytic domain expressed in Escherichia coli using p-nitrophenyl phosphate as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50587730(CHEMBL5208728)
Affinity DataIC50: 990nMAssay Description:Inhibition of human recombinant SHP2 expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 2 mins followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50587728(CHEMBL5175315)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of SHP2 (unknown origin) using EFpYAEVGRSPPDPAK incubated for 0.5 hrs by by malachite green reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50587729(CHEMBL5197620)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human recombinant SHP2 expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 2 mins followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50587731(CHEMBL5200672)
Affinity DataIC50: 8.79E+3nMAssay Description:Inhibition of recombinant human GST-tagged SHP2 expressed in Escherichia coli BL21 incubated for 30 mins by DiFMUP fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50587734(CHEMBL5194477)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of GST-tagged SHP2 (unknown origin) using 8-difluoro-4-methylumbelliferyl phosphate as a substrate measured after 30 mins by fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed