Compile Data Set for Download or QSAR
Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 50012443
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557676(CHEMBL4763955)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557672(CHEMBL4788669)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557678(CHEMBL4754084)
Affinity DataIC50: 61nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557660(CHEMBL4783741)
Affinity DataIC50: 136nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557666(CHEMBL4786255)
Affinity DataIC50: 165nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557652(CHEMBL4793291)
Affinity DataIC50: 167nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557679(CHEMBL4793279)
Affinity DataIC50: 195nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557677(CHEMBL4750925)
Affinity DataIC50: 322nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557656(CHEMBL4783466)
Affinity DataIC50: 335nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557674(CHEMBL4795194)
Affinity DataIC50: 454nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557675(CHEMBL4743249)
Affinity DataIC50: 505nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Rat)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50: 545nMAssay Description:Inhibition of recombinant rat KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557673(CHEMBL4781553)
Affinity DataIC50: 573nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Mouse)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50: 622nMAssay Description:Inhibition of recombinant wild type mouse KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557682(CHEMBL4745211)
Affinity DataIC50: 744nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557683(CHEMBL4758890)
Affinity DataIC50: 778nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557659(CHEMBL4779088)
Affinity DataIC50: 977nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Mouse)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557676(CHEMBL4763955)
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of recombinant wild type mouse KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Mouse)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557678(CHEMBL4754084)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of recombinant wild type mouse KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557664(CHEMBL4750826)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557670(CHEMBL4744857)
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557658(CHEMBL4789512)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557685(CHEMBL4750807)
Affinity DataIC50: 1.88E+3nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557671(CHEMBL4740667)
Affinity DataIC50: 2.64E+3nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Mouse)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557672(CHEMBL4788669)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of recombinant wild type mouse KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557653(CHEMBL4763819)
Affinity DataIC50: 3.31E+3nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557665(CHEMBL4777757)
Affinity DataIC50: 4.47E+3nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557668(CHEMBL4751954)
Affinity DataIC50: 5.25E+3nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557681(CHEMBL4776478)
Affinity DataIC50: 6.28E+3nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557661(CHEMBL4759833)
Affinity DataIC50: 6.49E+3nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557684(CHEMBL4744290)
Affinity DataIC50: 9.29E+3nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of Cav1.2 (unknown origin) by patch clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557655(CHEMBL4793050)
Affinity DataIC50: 1.14E+4nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557669(CHEMBL4755742)
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50: 1.19E+4nMAssay Description:Inhibition of human ERG by patch clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCalcium-activated potassium channel subunit beta-1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50: 1.32E+4nMAssay Description:Inhibition of BK (unknown origin) by patch clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Mouse)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557666(CHEMBL4786255)
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of recombinant wild type mouse KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 2(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50: 1.64E+4nMAssay Description:Inhibition of KCNT2 (unknown origin) by patch clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Mouse)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557677(CHEMBL4750925)
Affinity DataIC50: 1.71E+4nMAssay Description:Inhibition of recombinant wild type mouse KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50: 1.85E+4nMAssay Description:Inhibition of Iks (unknown origin) by patch clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557654(CHEMBL4780006)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557667(CHEMBL4797412)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557663(CHEMBL4753774)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557662(CHEMBL4743513)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Mouse)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557679(CHEMBL4793279)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant wild type mouse KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily T member 1(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557657(CHEMBL4781377)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of human Nav1.5 by patch clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed