Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50013002
TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562041BDBM50562041(CHEMBL4745536)
Affinity DataIC50: 11nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562040BDBM50562040(CHEMBL4761736)
Affinity DataIC50: 17nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562039BDBM50562039(CHEMBL4753089)
Affinity DataIC50: 21nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562033BDBM50562033(CHEMBL4745850)
Affinity DataIC50: 34nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562029BDBM50562029(CHEMBL4747340)
Affinity DataIC50: 38nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562025BDBM50562025(CHEMBL4799315)
Affinity DataIC50: 42nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562037BDBM50562037(CHEMBL4795294)
Affinity DataIC50: 46nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562032BDBM50562032(CHEMBL4789409)
Affinity DataIC50: 95nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562035BDBM50562035(CHEMBL4746937)
Affinity DataIC50: 114nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562027BDBM50562027(CHEMBL4800075)
Affinity DataIC50: 118nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562031BDBM50562031(CHEMBL4762599)
Affinity DataIC50: 146nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562026BDBM50562026(CHEMBL4780295)
Affinity DataIC50: 214nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562036BDBM50562036(CHEMBL4744429)
Affinity DataIC50: 227nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562028BDBM50562028(CHEMBL4752576)
Affinity DataIC50: 478nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562024BDBM50562024(CHEMBL4753232)
Affinity DataIC50: 510nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562030BDBM50562030(CHEMBL4799873)
Affinity DataIC50: 520nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562038BDBM50562038(CHEMBL4776406)
Affinity DataIC50: 587nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50562034BDBM50562034(CHEMBL4743153)
Affinity DataIC50: 777nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed