Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 50017422
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50415001(GSK-256066 | CHEMBL570015 | GSK-256066 (3))
Affinity DataIC50: 0.00300nMAssay Description:Inhibition of human PDE4 expressed in Sf9 cells by non-linear regression analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAdenosine deaminase(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM22925(Covidarabine | (8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hyd...)
Affinity DataKi:  0.00300nMAssay Description:Binding affinity to human erythrocytic ADA assessed as inhibition constant by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAdenosine deaminase(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity to ADA (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAngiotensin-converting enzyme(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50367879(LISINOPRIL)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of angiotensin converting enzyme (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetLethal factor(Bacillus anthracis)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601786(CHEMBL5180162)
Affinity DataKi:  0.270nMAssay Description:Binding affinity to Bacillus anthracis lethal factor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM26526(BMCL181958 Compound 1 | CHEMBL148169 | (2R)-N-hydr...)
Affinity DataKi:  0.560nMAssay Description:Inhibition of porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.840nMAssay Description:Inhibition of human recombinant PDE4B by liquid scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAdenosine deaminase(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM28393((2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol | CHEM...)
Affinity DataKi:  1nMAssay Description:Binding affinity to ADA (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50166256(5-[4-(4-Bromo-phenoxy)-phenyl]-5-(4-isopropyl-pipe...)
Affinity DataIC50: 1nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human H-rasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAdenosine deaminase(Mouse)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM22948(CHEMBL93560 | 1-[(3R,4S)-4-hydroxy-1-(naphthalen-1...)
Affinity DataKi:  3.60nMAssay Description:Binding affinity to recombinant mouse ADA assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601784(CHEMBL5206579)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human ADAM10 using (biotin-SPLAQAVRSSSRTP(3H)S-NH2) as a substrate by streptavidin-coated scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetLethal factor(Bacillus anthracis)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601785(CHEMBL5203076)
Affinity DataKi:  6.40nMAssay Description:Binding affinity to Bacillus anthracis lethal factor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetLethal factor(Bacillus anthracis)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM19(KDR Kinase Inhibitor, 3 | Neomycin | (2S,3S,4R,5R,...)
Affinity DataKi:  7nMAssay Description:Binding affinity to Bacillus anthracis lethal factor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGTPase KRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of human K-rasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50565139(Tasquinimod)
Affinity DataKd:  10nMAssay Description:Inhibition of human N-terminal flag-tag full-length wild-type HDAC4 by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50203527(methyl (6S,7S)-7-[(hydroxyamino)carbonyl]-6-[(4-ph...)
Affinity DataIC50: 14nMAssay Description:Inhibition of porcine ADAM17 using (7-methoxycour-marin-4-yl)-acetyl-Pro-Leu-Ala-Gln-Ala-Val-(3-[2,4-dinitrophenyl]- L -2, 3-diaminopropionyl)-Arg-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50203527(methyl (6S,7S)-7-[(hydroxyamino)carbonyl]-6-[(4-ph...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human ADAM10 using (7-methoxycour-marin-4-yl)-acetyl-Pro-Leu-Ala-Gln-Ala-Val-(3-[2,4-dinitrophenyl]- L -2, 3-diaminopropionyl)-Arg-Ser-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetLethal factor(Bacillus anthracis)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM8503((2R)-2-[(4-fluoro-3-methylphenyl)sulfonylamino]-N-...)
Affinity DataKi:  24nMAssay Description:Binding affinity to Bacillus anthracis lethal factor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50: 95nMAssay Description:Inhibition of human recombinant PDE4B by liquid scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetLethal factor(Bacillus anthracis)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50070942((-)-Epigallocatechin-3-o-gallate | (-)-Epigallocat...)
Affinity DataIC50: 97nMAssay Description:Inhibition of Bacillus anthracis lethal factorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM23274(BMCL176463 Compound 2 | BMC173072 Compound 2 | (2E...)
Affinity DataKi:  300nMAssay Description:Binding affinity to Clostridium botulinum BoNT/A light chain assessed as inhibition constant using SNAPtide as substrate by HPLC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM23274(BMCL176463 Compound 2 | BMC173072 Compound 2 | (2E...)
Affinity DataIC50: 400nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain using SNAPtide as substrate by HPLC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAngiotensin-converting enzyme(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataIC50: 420nMAssay Description:Inhibition of angiotensin converting enzyme (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601784(CHEMBL5206579)
Affinity DataIC50: 541nMAssay Description:Inhibition of human ADAM17More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed