Compile Data Set for Download or QSAR
Report error Found 78 Enz. Inhib. hit(s) with all data for entry = 50016431
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594947(VAFIDEMSTAT | Vafidemstat | ORY-2001)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of KDM1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50568531(CHEMBL4855475)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant human KDM1A (172 to 852 residues) using Bio-H3K4me2 peptide as substrate incubated for 1 hr by Lance ultra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594949(CHEMBL608561 | SJ000112537)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of KDM1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594950(CHEMBL5196914)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of MAO-A (unknown origin) by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50236444(CHEMBL4090812)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of recombinant human KDM1A (158 to 852 residues) using H3K4Me2 peptide as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5C(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594968(CHEMBL5199483)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of N-terminal FLAG/His-tagged full-length human KDM5C (2 to 1560 residues) expressed in baculovirus infected Sf9 insect cells using peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific demethylase 5A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594967(CHEMBL5175566)
Affinity DataIC50: 24nMAssay Description:Inhibition of full-length human KDM5A expressed in recombinant baculovirus expression system using H3K9me3 peptide as substrate incubated for 30 to 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50548033(CHEMBL4743670)
Affinity DataIC50: 29nMAssay Description:Inhibition of KDM1A (unknown origin) incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50551861(CHEMBL4798849)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human KDM1A using fluorogenic substrate incubated for 30 mins followed by substrate addition measured after 10 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594946(CHEMBL4596515)
Affinity DataIC50: 51nMAssay Description:Inhibition of KDM1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594952(CHEMBL5177724)
Affinity DataIC50: 58nMAssay Description:Inhibition of recombinant human KMD1A using H3K4Me2 peptide as substrate preincubated for 15 mins followed by substrate addition measured after 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594960(CHEMBL5182796)
Affinity DataIC50: 63nMAssay Description:Inhibition of recombinant KDM1A (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594955(CHEMBL5190775)
Affinity DataIC50: 110nMAssay Description:Inhibition of KDM1A (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50568524(CHEMBL4847919)
Affinity DataIC50: 123nMAssay Description:Inhibition of KDM1A (unknown origin) incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific demethylase 3B(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594964(CHEMBL5193187)
Affinity DataKd:  130nMAssay Description:Binding affinity to CM7 sensor chip immobilized full-length KDM3B (unknown origin) expressed in Sf9 insect cells assessed as dissociation constant in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50986(SMR000232286 | MLS000563434 | cid_160876)
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant KDM1A (unknown origin) expressed in Escherichia coli BL21 using H3K4Me2 peptide as substrate preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594961(CHEMBL5201233)
Affinity DataIC50: 140nMAssay Description:Inhibition of full-length KDM1A (unknown origin) expressed in Escherichia coli BL21 DE by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50346870(CHEMBL1797647)
Affinity DataKd:  140nMAssay Description:Binding affinity to human KDM1A (514 to 2499 residues) expressed in Escherichia coli Rosetta 2 assessed as dissociation constant by SPR Biosensor ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50587726(CHEMBL3401107)
Affinity DataIC50: 183nMAssay Description:Inhibition of full-length recombinant KDM1A (unknown origin) expressed in Escherichia coli BL21 DE using H3K4Me2 peptide as substrate incubated for 0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594958(CHEMBL5204771)
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant human KDM1A using fluorogenic substrate incubated for 30 mins followed by substrate addition measured after 10 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50236898((1S,2R)-(+)-2-phenylcyclopropylamine | trans-2-phe...)
Affinity DataIC50: 269nMAssay Description:Inhibition of MAO-A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594948(CHEMBL5181906)
Affinity DataIC50: 296nMAssay Description:Inhibition of KDM1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetREST corepressor 1(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50568518(CHEMBL4877195)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant human KDM1A/CoREST expressed in Escherichia coli using mono-methylated H3-K4 peptide as substrate preincubated for 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594951(CHEMBL5174572)
Affinity DataKi:  370nMAssay Description:Binding affinity to human KDM1A (172 to 833 residues) assessed as inhibition constant using Lys4-dimethylated H3 peptide as substrate incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594954(CHEMBL3330503)
Affinity DataIC50: 407nMAssay Description:Inhibition of full-length recombinant KDM1A (unknown origin) expressed in Escherichia coli BL21 DE using H3K4Me2 peptide as substrate incubated for 0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50226664(2-hydroxy-3,9,10-trimethoxy-5,6-dihydroisoquino[3,...)
Affinity DataIC50: 470nMAssay Description:Inhibition of recombinant KDM1A (unknown origin) expressed in Escherichia coli BL21 using H3K4Me2 peptide as substrate preincubated for 10 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50236898((1S,2R)-(+)-2-phenylcyclopropylamine | trans-2-phe...)
Affinity DataIC50: 507nMAssay Description:Inhibition of MAO-B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50548033(CHEMBL4743670)
Affinity DataIC50: 526nMAssay Description:Inhibition of recombinant MAO-A (unknown origin) using 5-hydroxytryptamine as substrate incubated for 20 mins followed by substrate addition measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM20461(Zostrix | (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl...)
Affinity DataIC50: 600nMAssay Description:Inhibition of KDM1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50548033(CHEMBL4743670)
Affinity DataIC50: 702nMAssay Description:Inhibition of recombinant MAO-B (unknown origin) using benzylamine as substrate incubated for 20 mins followed by substrate addition measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50568526(CHEMBL4856722)
Affinity DataIC50: 780nMAssay Description:Inhibition of recombinant human KDM1A (172 to 852 residues) using Bio-H3K4me2 peptide as substrate incubated for 1 hr by Lance ultra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50568524(CHEMBL4847919)
Affinity DataIC50: 807nMAssay Description:Inhibition of recombinant MAO-A (unknown origin) using 5-hydroxytryptamine as substrate incubated for 20 mins followed by substrate addition measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50568524(CHEMBL4847919)
Affinity DataIC50: 898nMAssay Description:Inhibition of recombinant MAO-B (unknown origin) using benzylamine as substrate incubated for 20 mins followed by substrate addition measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594953(HIGENAMINE | CHEBI:18418 | Dl-demethylcoclaurine |...)
Affinity DataIC50: 1.47E+3nMAssay Description:Inhibition of full-length recombinant KDM1A (unknown origin) expressed in Escherichia coli BL21 DE using H3K4Me2 peptide as substrate incubated for 0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM19441(Evista | CHEMBL81 | Keoxifene | Raloxifene, 6 | RA...)
Affinity DataIC50: 2.08E+3nMAssay Description:Inhibition of KDM1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594956(DEHYDROCORYDALINE | CHEBI:81342 | Dehydrocorydalin...)
Affinity DataIC50: 2.44E+3nMAssay Description:Inhibition of KDM1A (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50568531(CHEMBL4855475)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of MAO-A (unknown origin) by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetProbable JmjC domain-containing histone demethylation protein 2C(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594964(CHEMBL5193187)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to CM7 sensor chip immobilized partial-length JMJD1C (2274 to 2498 residues) (unknown origin) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50214969(Mangostin | alpha-mangostin | 1,3,6-Trihydroxy-7-m...)
Affinity DataIC50: 2.81E+3nMAssay Description:Inhibition of KDM1A (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM9461(5,7-dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one...)
Affinity DataIC50: 2.95E+3nMAssay Description:Inhibition of recombinant KDM1A (unknown origin) using H3K4Me2 peptide as substrate incubated for 0.5 hrs by Amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific demethylase 6B(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50088376(CHEBI:49005 | Deferasirox | Exjade | ICL670A | US1...)
Affinity DataIC50: 3.95E+3nMAssay Description:Inhibition of KDM6B (1043 to end residues) (unknown origin) using ATKAARK(me3)-SAPATGGVKKPHRYRPG-GK(biotin) as substrate preincubated for 10 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594957(ISOGERMAFURENOLIDE | Isogermafurenolide)
Affinity DataIC50: 3.97E+3nMAssay Description:Inhibition of KDM1A (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of KDM1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594959(CHEMBL5187087)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of recombinant human KDM1A (158 to 852 residues) using H3K4Me2 peptide as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific demethylase 6A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50525976(CHEBI:68554 | APO-066 | APO-66 | CP-20 | CP20 | DN...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of KDM6A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific demethylase 4A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50088376(CHEBI:49005 | Deferasirox | Exjade | ICL670A | US1...)
Affinity DataIC50: 4.76E+3nMAssay Description:Inhibition of KDM4A (1 to 359 residues) (unknown origin) using ARTKQTARK(me3)-STGGKAPRKQLA-GGK(biotin) peptide as substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50594950(CHEMBL5196914)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of recombinant human KMD1A (172 to 852 residues) using Bio-H3K4me2 peptide as substrate incubated for 1 hr by Lance ultra TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific demethylase 5A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50088376(CHEBI:49005 | Deferasirox | Exjade | ICL670A | US1...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of full-length KDM5A (1 to 1090 residues)(unknown origin) using ARTK(me3)-QTARKSTGGKAPRKQLA-GGK(biotin) as substrate preincubated for 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific demethylase 5C(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50525976(CHEBI:68554 | APO-066 | APO-66 | CP-20 | CP20 | DN...)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of KDM5C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetLysine-specific demethylase 2A(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50525976(CHEBI:68554 | APO-066 | APO-66 | CP-20 | CP20 | DN...)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of KDM2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
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