Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 50014981
TargetMonoglyceride lipase(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM581678((2s,4S)-N-((1s,3S)-3-(4-Isopropylphenyl)cyclobutyl...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of human MAGL expressed in HeLa cells using [glycerol-1, 3-3H]-oleoyl glycerol as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM581668((2s,4S)-N-((1s,3S)-3-(4-(tert-Butyl)phenyl)cyclobu...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human MAGL expressed in HeLa cells using [glycerol-1, 3-3H]-oleoyl glycerol as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM581697((2s,4S)-N-((1s,3S)-3-(4-Cyclopropyl-3-methylphenyl...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human MAGL expressed in HeLa cells using [glycerol-1, 3-3H]-oleoyl glycerol as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM581706((2s,4S)-N-Methyl-N-((1s,3S)-3-(4-(1-methylcyclopro...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human MAGL expressed in HeLa cells using [glycerol-1, 3-3H]-oleoyl glycerol as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM581679((2s,4S)-N-((1s,3S)-3-(3-(tert-Butyl)-4-fluoropheny...)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of human MAGL expressed in HeLa cells using [glycerol-1, 3-3H]-oleoyl glycerol as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM581710(US11512059, Example 44 | (2s,4S)-N-((1s,3S)-3-(3-C...)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of human MAGL expressed in HeLa cells using [glycerol-1, 3-3H]-oleoyl glycerol as substrate incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed