Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 50015404
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586310BDBM50586310(CHEMBL5093029)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586307BDBM50586307(CHEMBL5087826)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586289BDBM50586289(CHEMBL5070887)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of ERK1 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586299BDBM50586299(CHEMBL5076561)
Affinity DataIC50: 3nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586306BDBM50586306(CHEMBL5089637)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586300BDBM50586300(CHEMBL5082830)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586289BDBM50586289(CHEMBL5070887)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586296BDBM50586296(CHEMBL5092545)
Affinity DataIC50: 6nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586301BDBM50586301(CHEMBL5073083)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586292BDBM50586292(CHEMBL5086221)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586305BDBM50586305(CHEMBL5081036)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50094465BDBM50094465(CHEMBL3590106 | US10525036, Example BVD-523 | US10...)
Affinity DataIC50: 11nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586294BDBM50586294(CHEMBL5085508)
Affinity DataIC50: 14nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586289BDBM50586289(CHEMBL5070887)
Affinity DataIC50: 14nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586308BDBM50586308(CHEMBL5076006)
Affinity DataIC50: 16nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586311BDBM50586311(CHEMBL5090465)
Affinity DataIC50: 18nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586302BDBM50586302(CHEMBL5077010)
Affinity DataIC50: 39nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586309BDBM50586309(CHEMBL5092813)
Affinity DataIC50: 45nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586289BDBM50586289(CHEMBL5070887)
Affinity DataIC50: 64nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586295BDBM50586295(CHEMBL5085912)
Affinity DataIC50: 99nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586289BDBM50586289(CHEMBL5070887)
Affinity DataIC50: 99nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586298BDBM50586298(CHEMBL5094193)
Affinity DataIC50: 130nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586303BDBM50586303(CHEMBL5091739)
Affinity DataIC50: 188nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586291BDBM50586291(CHEMBL5080686)
Affinity DataIC50: 201nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586289BDBM50586289(CHEMBL5070887)
Affinity DataIC50: 224nMAssay Description:Inhibition of ERK1/2 in human COLO 205 cells assessed as inhibition of RSK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586304BDBM50586304(CHEMBL5086119)
Affinity DataIC50: 237nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586290BDBM50586290(CHEMBL5078454)
Affinity DataIC50: 240nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586299BDBM50586299(CHEMBL5076561)
Affinity DataIC50: 350nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586289BDBM50586289(CHEMBL5070887)
Affinity DataIC50: 790nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586297BDBM50586297(CHEMBL5093914)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586293BDBM50586293(CHEMBL5088768)
Affinity DataIC50: 4.83E+3nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586299BDBM50586299(CHEMBL5076561)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586299BDBM50586299(CHEMBL5076561)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586289BDBM50586289(CHEMBL5070887)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586289BDBM50586289(CHEMBL5070887)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586299BDBM50586299(CHEMBL5076561)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586289BDBM50586289(CHEMBL5070887)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586299BDBM50586299(CHEMBL5076561)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586289BDBM50586289(CHEMBL5070887)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586289BDBM50586289(CHEMBL5070887)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50586289BDBM50586289(CHEMBL5070887)
Affinity DataIC50: 1.15E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed