Compile Data Set for Download or QSAR
Report error Found 111 Enz. Inhib. hit(s) with all data for entry = 50016962
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598680(CHEMBL5173517)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598681(CHEMBL5200991)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598682(CHEMBL5206444)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598673(CHEMBL5207390)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598683(CHEMBL5196495)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598668(CHEMBL5195164)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598685(CHEMBL5208737)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598675(CHEMBL5185207)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598684(CHEMBL5194722)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598687(CHEMBL5193016)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR ex19del(746 to 750)/ T790M/C790S mutant (668 to end residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR ex19del(746 to 750)/T790M mutant (668 to end residues) expressed in baculovirus infected S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598679(CHEMBL5170376)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598683(CHEMBL5196495)
Affinity DataIC50: 1nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598678(CHEMBL5187021)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598681(CHEMBL5200991)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598684(CHEMBL5194722)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598674(CHEMBL5172587)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598667(CHEMBL5208679)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598671(CHEMBL5182741)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598687(CHEMBL5193016)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598682(CHEMBL5206444)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) expressed in mouse BaF3 cells assessed as inhibition of protein phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598676(CHEMBL5205583)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598672(CHEMBL5203267)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598685(CHEMBL5208737)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598680(CHEMBL5173517)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598668(CHEMBL5195164)
Affinity DataIC50: 7nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598673(CHEMBL5207390)
Affinity DataIC50: 7nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R mutant (668 to end residues) expressed in baculovirus infected Sf9 insect cells expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598666(CHEMBL5185287)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598679(CHEMBL5170376)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598677(CHEMBL5198992)
Affinity DataIC50: 11nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598674(CHEMBL5172587)
Affinity DataIC50: 13nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598670(CHEMBL5184941)
Affinity DataIC50: 16nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598689(CHEMBL5169349)
Affinity DataIC50: 17nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598675(CHEMBL5185207)
Affinity DataIC50: 19nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598667(CHEMBL5208679)
Affinity DataIC50: 20nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598666(CHEMBL5185287)
Affinity DataIC50: 20nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598671(CHEMBL5182741)
Affinity DataIC50: 23nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598676(CHEMBL5205583)
Affinity DataIC50: 24nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 25nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR ex19del (746 to 750) mutant expressed in baculovirus infected Sf9 insect cells expression ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598670(CHEMBL5184941)
Affinity DataIC50: 25nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598678(CHEMBL5187021)
Affinity DataIC50: 32nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | Blu-945 | BLU945)
Affinity DataIC50: 40nMAssay Description:Inhibition of EGFR ex19del/T790M/C797S triple mutant (unknown origin) expressed in mouse BaF3 cells assessed as inhibition of protein phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598677(CHEMBL5198992)
Affinity DataIC50: 40nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598672(CHEMBL5203267)
Affinity DataIC50: 41nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598665(CHEMBL5188960)
Affinity DataIC50: 50nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
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