Compile Data Set for Download or QSAR
Report error Found 92 Enz. Inhib. hit(s) with all data for entry = 50016511
TargetAdenosine receptor A2b(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50150074(2-Amino-4-(4-hydroxy-phenyl)-6-(1H-imidazol-2-ylme...)
Affinity DataKi:  1nMAssay Description:Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2b(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50150074(2-Amino-4-(4-hydroxy-phenyl)-6-(1H-imidazol-2-ylme...)
Affinity DataKd:  1.10nMAssay Description:Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as affinity on-rate by surface plasmon resonance assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2b(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50275499(2-(4-fluorophenyl)-3-(4-pyridinyl)pyrazolo-[1,5-a]...)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as affinity off-rate by surface plasmon resonance ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2b(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50275499(2-(4-fluorophenyl)-3-(4-pyridinyl)pyrazolo-[1,5-a]...)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as affinity on-rate by surface plasmon resonance assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM21190(CHEMBL113142 | 4-(2-{[5-amino-2-(furan-2-yl)-[1,2,...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human adenosine A2A receptor expressed in HEK293T cells assessed as inhibition of NECA-induced Gs short protein activation by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50581950(CHEMBL4204703)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to human wild type adenosine A1 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50581950(CHEMBL4204703)
Affinity DataKd:  6.30nMAssay Description:Binding affinity to human wild type adenosine A1 receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM8392(CHEMBL408564 | N-[5-bromo-6-(furan-2-yl)-1H-pyrazo...)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human GSKalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM82022(N6-Phenylado | 2-[6-Amino-2-(3-cyclohexyl-propylam...)
Affinity DataKd:  9.10nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM14487([U-14C]adenosine | CHEMBL477 | cid_60961 | (2R,3R,...)
Affinity DataKd:  17nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM82022(N6-Phenylado | 2-[6-Amino-2-(3-cyclohexyl-propylam...)
Affinity DataKi:  76nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM8246(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophe...)
Affinity DataIC50: 94nMAssay Description:Inhibition of recombinant human GSKalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595384(CHEMBL63803)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human GSKalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM8246(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophe...)
Affinity DataKd:  110nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM14487([U-14C]adenosine | CHEMBL477 | cid_60961 | (2R,3R,...)
Affinity DataKi:  150nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50520329(CHEMBL4550896)
Affinity DataIC50: 166nMAssay Description:Antagonist activity at human adenosine A2A receptor expressed in HEK293T cells assessed as inhibition of NECA-induced Gs short protein activation by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2b(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50275499(2-(4-fluorophenyl)-3-(4-pyridinyl)pyrazolo-[1,5-a]...)
Affinity DataKd:  280nMAssay Description:Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM21190(CHEMBL113142 | 4-(2-{[5-amino-2-(furan-2-yl)-[1,2,...)
Affinity DataKd:  286nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM14487([U-14C]adenosine | CHEMBL477 | cid_60961 | (2R,3R,...)
Affinity DataKi:  290nMAssay Description:Binding affinity to human wild type adenosine A3 receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM21190(CHEMBL113142 | 4-(2-{[5-amino-2-(furan-2-yl)-[1,2,...)
Affinity DataKi:  395nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM8392(CHEMBL408564 | N-[5-bromo-6-(furan-2-yl)-1H-pyrazo...)
Affinity DataKd:  560nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM14487([U-14C]adenosine | CHEMBL477 | cid_60961 | (2R,3R,...)
Affinity DataKd:  740nMAssay Description:Binding affinity to human wild type adenosine A3 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50275499(2-(4-fluorophenyl)-3-(4-pyridinyl)pyrazolo-[1,5-a]...)
Affinity DataKd:  740nMAssay Description:Binding affinity to human wild type adenosine A3 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595383(CHEMBL5201800)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to human wild type adenosine A1 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50207720(CHEMBL3954022)
Affinity DataKd:  1.11E+3nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595384(CHEMBL63803)
Affinity DataKd:  1.21E+3nMAssay Description:Binding affinity to human wild type adenosine A1 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595380(BENZOGUANAMINE)
Affinity DataKd:  1.50E+3nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM8392(CHEMBL408564 | N-[5-bromo-6-(furan-2-yl)-1H-pyrazo...)
Affinity DataKd:  2.12E+3nMAssay Description:Binding affinity to human wild type adenosine A1 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595380(BENZOGUANAMINE)
Affinity DataKd:  2.21E+3nMAssay Description:Binding affinity to human wild type adenosine A1 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM8246(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophe...)
Affinity DataKd:  2.21E+3nMAssay Description:Binding affinity to human wild type adenosine A1 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2b(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50150074(2-Amino-4-(4-hydroxy-phenyl)-6-(1H-imidazol-2-ylme...)
Affinity DataKd:  3.07E+3nMAssay Description:Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKd:  3.63E+3nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM10849(CHEMBL113 | 1,3,7-trimethyl-3,7-dihydropurine-2,6-...)
Affinity DataKd:  5.51E+3nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50275499(2-(4-fluorophenyl)-3-(4-pyridinyl)pyrazolo-[1,5-a]...)
Affinity DataKd:  6.05E+3nMAssay Description:Binding affinity to human wild type adenosine A1 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595382(CHEMBL5208068)
Affinity DataKd:  7.60E+3nMAssay Description:Binding affinity to human wild type adenosine A1 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50275499(2-(4-fluorophenyl)-3-(4-pyridinyl)pyrazolo-[1,5-a]...)
Affinity DataKd:  8.90E+3nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595377(Pteridine-2,4-Diamine | CHEMBL336555)
Affinity DataKd:  9.60E+3nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595382(CHEMBL5208068)
Affinity DataKd:  1.35E+4nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595382(CHEMBL5208068)
Affinity DataKd:  1.80E+4nMAssay Description:Binding affinity to human wild type adenosine A3 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595378(CHEMBL5204663)
Affinity DataKd:  1.89E+4nMAssay Description:Binding affinity to human wild type adenosine A3 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2b(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595382(CHEMBL5208068)
Affinity DataKd:  1.93E+4nMAssay Description:Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595381(CHEMBL5184937)
Affinity DataKd:  2.07E+4nMAssay Description:Binding affinity to human wild type adenosine A1 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595381(CHEMBL5184937)
Affinity DataKd:  2.18E+4nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2b(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595372(CHEMBL5195119)
Affinity DataKd:  2.20E+4nMAssay Description:Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50207720(CHEMBL3954022)
Affinity DataKd:  2.29E+4nMAssay Description:Binding affinity to human wild type adenosine A1 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595374(CHEMBL5197070)
Affinity DataKd:  2.70E+4nMAssay Description:Binding affinity to human wild type adenosine A1 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595378(CHEMBL5204663)
Affinity DataKd:  2.88E+4nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595373(CHEMBL5197657)
Affinity DataKd:  3.18E+4nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595378(CHEMBL5204663)
Affinity DataKd:  3.43E+4nMAssay Description:Binding affinity to human wild type adenosine A1 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50595381(CHEMBL5184937)
Affinity DataKd:  3.65E+4nMAssay Description:Binding affinity to human wild type adenosine A3 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
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