Compile Data Set for Download or QSAR
Report error Found 69 Enz. Inhib. hit(s) with all data for entry = 50019164
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616024BDBM50616024(CHEMBL5420034)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616032BDBM50616032(CHEMBL5429186)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616040BDBM50616040(CHEMBL5418335)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616024BDBM50616024(CHEMBL5420034)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 36609BDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50088378BDBM50088378(CHEBI:68478 | Afinitor | Afinitor Disperz | Everol...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616032BDBM50616032(CHEMBL5429186)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616027BDBM50616027(CHEMBL5430111)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616047BDBM50616047(CHEMBL5441038)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616045BDBM50616045(CHEMBL5422529)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616028BDBM50616028(CHEMBL5404497)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616044BDBM50616044(RMC-5552 | Rmc-5552)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616036BDBM50616036(CHEMBL5419721)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616046BDBM50616046(CHEMBL5399980)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616026BDBM50616026(CHEMBL5430354)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616037BDBM50616037(CHEMBL5413401)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616042BDBM50616042(CHEMBL5422229)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616030BDBM50616030(CHEMBL5408375)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616033BDBM50616033(CHEMBL5404617)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616025BDBM50616025(CHEMBL5427995)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616023BDBM50616023(CHEMBL5440792)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616029BDBM50616029(CHEMBL5394998)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616034BDBM50616034(CHEMBL5419762)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616041BDBM50616041(CHEMBL5431157)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616021BDBM50616021(CHEMBL5422165)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616036BDBM50616036(CHEMBL5419721)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616047BDBM50616047(CHEMBL5441038)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616027BDBM50616027(CHEMBL5430111)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616022BDBM50616022(CHEMBL5425648)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616045BDBM50616045(CHEMBL5422529)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616043BDBM50616043(CHEMBL5434290)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616031BDBM50616031(CHEMBL5416606)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616035BDBM50616035(CHEMBL5418134)
Affinity DataIC50: 0.610nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616028BDBM50616028(CHEMBL5404497)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 315477BDBM315477(US10172858, Table 1.22 | US10172858, Table 1.1)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616037BDBM50616037(CHEMBL5413401)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616020BDBM50616020(CHEMBL5424277)
Affinity DataIC50: 0.930nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616046BDBM50616046(CHEMBL5399980)
Affinity DataIC50: 0.970nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616026BDBM50616026(CHEMBL5430354)
Affinity DataIC50: 1nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616033BDBM50616033(CHEMBL5404617)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616021BDBM50616021(CHEMBL5422165)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616042BDBM50616042(CHEMBL5422229)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616023BDBM50616023(CHEMBL5440792)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616043BDBM50616043(CHEMBL5434290)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616044BDBM50616044(RMC-5552 | Rmc-5552)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616020BDBM50616020(CHEMBL5424277)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616035BDBM50616035(CHEMBL5418134)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616022BDBM50616022(CHEMBL5425648)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50616025BDBM50616025(CHEMBL5427995)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 36609BDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataEC50: <10nMAssay Description:Inhibition of recombinant human EmGFP fused FKBP12/GST-tagged human mTOR (1360 to 2549 residues) FRB domain incubated for 1 hrs by LanthaScreen based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
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