Compile Data Set for Download or QSAR
Report error Found 140 Enz. Inhib. hit(s) with all data for entry = 50020672
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632579(CHEMBL5424894)
Affinity DataKd:  0.00200nMAssay Description:Binding affinity to TYK2 JH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632583(CHEMBL5403297)
Affinity DataKd:  0.00200nMAssay Description:Binding affinity to TYK2 JH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM424361(US10508120, Compound I-816 | US10508120, Compound ...)
Affinity DataKd:  0.00400nMAssay Description:Binding affinity to human wild-type partial length TYK2 JH2 (G556 to D888 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632576(CHEMBL5439447)
Affinity DataKd:  0.00500nMAssay Description:Binding affinity to human wild-type partial length TYK2 JH2 (G556 to D888 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632578(CHEMBL5416592)
Affinity DataKd:  0.00800nMAssay Description:Binding affinity to human wild-type partial length TYK2 JH2 (G556 to D888 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632577(CHEMBL5436959)
Affinity DataKd:  0.00900nMAssay Description:Binding affinity to human wild-type partial length TYK2 JH2 (G556 to D888 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632588(CHEMBL5427277)
Affinity DataIC50: 0.0160nMAssay Description:Inhibition of TYK2 JH2 (561 to 860 residues) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632592(CHEMBL5422022)
Affinity DataIC50: 0.0180nMAssay Description:Inhibition of TYK2 JH2 (561 to 860 residues) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632595(CHEMBL5418288)
Affinity DataIC50: 0.0260nMAssay Description:Inhibition of TYK2 JH2 (561 to 860 residues) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632593(CHEMBL5416227)
Affinity DataIC50: 0.0260nMAssay Description:Inhibition of TYK2 JH2 (561 to 860 residues) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632594(CHEMBL5420349)
Affinity DataIC50: 0.0270nMAssay Description:Inhibition of TYK2 JH2 (561 to 860 residues) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM515659(US11053219, Example 28 | BDBM515661 | US11053219, ...)
Affinity DataKd:  0.0280nMAssay Description:Binding affinity to human wild-type partial length TYK2 JH2 (G556 to D888 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632589(CHEMBL5417355)
Affinity DataIC50: 0.0380nMAssay Description:Inhibition of TYK2 JH2 (561 to 860 residues) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632595(CHEMBL5418288)
Affinity DataIC50: 0.0530nMAssay Description:Inhibition of JAK2/TYK2 signal transduction pathway in human NK92 cells assessed as IL-12 induced STAT4 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632568(CHEMBL5420928)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of human recombinant TYK2 preincubated for 15 mins followed by substrate addition measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632567(CHEMBL5413489)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of human recombinant TYK2 preincubated for 15 mins followed by substrate addition measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632568(CHEMBL5420928)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of JAK2/TYK2 signal transduction pathway in human NK92 cells assessed as IL-2 induced IFNgamma expression incubated for 24 hrs by ELISA as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632566(CHEMBL5440264)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant TYK2 preincubated for 15 mins followed by substrate addition measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632567(CHEMBL5413489)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of JAK2/TYK2 signal transduction pathway in human NK92 cells assessed as IL-2 induced IFNgamma expression incubated for 24 hrs by ELISA as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632588(CHEMBL5427277)
Affinity DataIC50: 0.310nMAssay Description:Inhibition of JAK1 JH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632566(CHEMBL5440264)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of JAK2/TYK2 signal transduction pathway in human NK92 cells assessed as IL-2 induced IFNgamma expression incubated for 24 hrs by ELISA as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632597(CHEMBL5409126)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of TYK2 JH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632584(CHEMBL5396851)
Affinity DataKd: <1nMAssay Description:Binding affinity to TYK2 JH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632585(CHEMBL5418587)
Affinity DataKd: <1nMAssay Description:Binding affinity to TYK2 JH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632594(CHEMBL5420349)
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK2/TYK2 signal transduction pathway in human NK92 cells assessed as IL-12 induced STAT4 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632568(CHEMBL5420928)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant JAK3 preincubated for 15 mins followed by substrate addition measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632574(CHEMBL5401457)
Affinity DataEC50: <1nMAssay Description:Inhibition of JAK2/TYK2 in HEK-Blue IL-23 cells assessed as reduction in SEAP reporter gene expression incubated for 21 hrs by Quanti-blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632581(CHEMBL5431527)
Affinity DataIC50: 1nMAssay Description:Inhibition of TYK2 in HEK-Blue IL-23 cells assessed as reduction in SEAP reporter gene expression by Quanti-blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632582(CHEMBL5400869)
Affinity DataIC50: 1nMAssay Description:Inhibition of TYK2 in HEK-Blue IL-23 cells assessed as reduction in SEAP reporter gene expression by Quanti-blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632592(CHEMBL5422022)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of JAK1 JH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632579(CHEMBL5424894)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of TYK2 signal transduction pathway in human PBMC cells assessed as IFNalpha induced p-STAT5 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632592(CHEMBL5422022)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of JAK2/TYK2 signal transduction pathway in human NK92 cells assessed as IL-12 induced STAT4 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632583(CHEMBL5403297)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of TYK2 signal transduction pathway in human PBMC cells assessed as IFNalpha induced p-STAT5 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632593(CHEMBL5416227)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of JAK2/TYK2 signal transduction pathway in human NK92 cells assessed as IL-12 induced STAT4 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632596(CHEMBL5397906)
Affinity DataIC50: 2nMAssay Description:Inhibition of JAK2/TYK2 signal transduction pathway in human PBMC cells assessed as IL-23 induced p-STAT4 level by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM576242(WO2022109580, Example 1)
Affinity DataKi:  2nMAssay Description:Binding affinity to His-tagged human recombinant TYK2 JH2 (556 to 871 residues) incubated for 10 hrs by microplate reader based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632596(CHEMBL5397906)
Affinity DataKi:  2nMAssay Description:Binding affinity to His-tagged human recombinant TYK2 JH2 (556 to 871 residues) incubated for 10 hrs by microplate reader based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632598(CHEMBL5439751)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of TYK2 JH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632580(CHEMBL5437070)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human Jurkat cells incubated for 30 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM576242(WO2022109580, Example 1)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2/TYK2 signal transduction pathway in human PBMC cells assessed as IL-23 induced p-STAT4 level by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM515659(US11053219, Example 28 | BDBM515661 | US11053219, ...)
Affinity DataKd:  3.70nMAssay Description:Binding affinity to JAK1 JH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632568(CHEMBL5420928)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant JAK2 preincubated for 15 mins followed by substrate addition measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632567(CHEMBL5413489)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant JAK2 preincubated for 15 mins followed by substrate addition measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632576(CHEMBL5439447)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human KIT225 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632571(CHEMBL5405538)
Affinity DataIC50: 7nMAssay Description:Inhibition of TYK2 JH2 in human TF-1 cells assessed as reduction of IFNalpha induced STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632571(CHEMBL5405538)
Affinity DataIC50: 7nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human KIT225 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632567(CHEMBL5413489)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant JAK3 preincubated for 15 mins followed by substrate addition measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632589(CHEMBL5417355)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of JAK1 JH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632570(CHEMBL5433451)
Affinity DataIC50: 8nMAssay Description:Inhibition of TYK2 JH2 in human TF-1 cells assessed as reduction of IFNalpha induced STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632596(CHEMBL5397906)
Affinity DataIC50: 8nMAssay Description:Inhibition of JAK2/TYK2 signal transduction pathway in human PBMC cells assessed as IL-12 induced p-STAT4 level by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
Displayed 1 to 50 (of 140 total ) | Next | Last >>
Jump to: