Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50020708
LigandPNGBDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of NIK (unknown origin) catalyzed ATP hydrolysis assessed as inhibition constant by fluorescence polarization methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM431871(1-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azab...)
Affinity DataKi:  0.880nMAssay Description:Inhibition of NIK (unknown origin) catalyzed ATP hydrolysis assessed as inhibition constant by fluorescence polarization methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM431871(1-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azab...)
Affinity DataIC50: 2nMAssay Description:Inhibition of NIK (unknown origin) catalyzed ATP hydrolysis by fluorescence polarization methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataIC50: 36nMAssay Description:Inhibition of NIK in HEK-293 cells assessed as inhibition of NIK-dependent NF-kappaB response element expression by firefly luciferase reporter gene ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataIC50: 36nMAssay Description:Inhibition of NIK in HUVEC cells assessed as inhibition of anti-LTf3R-stimulated p52 nuclear translocationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM431871(1-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azab...)
Affinity DataIC50: 53nMAssay Description:Inhibition of NIK in HEK-293 cells assessed as inhibition of NIK-dependent NF-kappaB response element expression by firefly luciferase reporter gene ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM431871(1-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azab...)
Affinity DataIC50: 55nMAssay Description:Inhibition of NIK in HUVEC cells assessed as inhibition of anti-LTf3R-stimulated p52 nuclear translocationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPolycystin-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM431871(1-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azab...)
Affinity DataKi:  64nMAssay Description:Inhibition of PKD1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPolycystin-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50457815(CHEMBL4211840)
Affinity DataKi:  66nMAssay Description:Inhibition of PKD1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPolycystin-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  89nMAssay Description:Inhibition of PKD1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPolycystin-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM431871(1-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azab...)
Affinity DataIC50: 210nMAssay Description:Inhibition of PKD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPolycystin-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50457815(CHEMBL4211840)
Affinity DataIC50: 220nMAssay Description:Inhibition of PKD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPolycystin-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataIC50: 300nMAssay Description:Inhibition of PKD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM431871(1-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azab...)
Affinity DataIC50: 330nMAssay Description:Inhibition of NIK in human primary B cell assessed as inhibition of CD40L-stimulated nuclear translocation of p52 in cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed