Compile Data Set for Download or QSAR
Report error Found 61 Enz. Inhib. hit(s) with all data for entry = 50022325
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of human VEGFR-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650863(CHEMBL5632719)
Affinity DataIC50: 0.770nMAssay Description:Inhibition of human VEGFR-2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50331096(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7...)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR-3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50331096(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant VEGFR-2 kinase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50331096(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50331096(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7...)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR-1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50331096(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50331096(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7...)
Affinity DataIC50: 1nMAssay Description:Inhibition of c-Kit (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM4627(5-[(6,7-dimethoxyquinazolin-4-yl)amino]-4-fluoro-2...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of KDR (unknown origin) using peptide substrate incubated for 90 mins in presence of ATP by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM167952(1-(4-(3-Methoxyphenyl)piperazin-1-yl)-3-(quinazoli...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650865(CHEMBL5632302)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human VEGFR-2 using biotinylated synthetic peptide biotin-aminohexyl-EEEEYFELVAKKKK-NH2 as substrate pre-incubated for 30 mins and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650867(CHEMBL5634036)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of N-terminal polyhistidine human recombinant KDR using poly-(Glu4-Tyr) peptide as substrate incubated for 60 mins by DELFIA/time-resolved...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50631721(CHEMBL5418423)
Affinity DataIC50: 7nMAssay Description:Inhibition of VEGFR-2 (unknown origin) kinase activity using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 60 mins by ELIS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50153906(CHEMBL3775169)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of KDR (unknown origin) using peptide substrate incubated for 90 mins in presence of ATP by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50635277(CHEMBL5523510)
Affinity DataIC50: 12nMAssay Description:Inhibition of VEGFR1 (unknown origin) by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650869(CHEMBL5632614)
Affinity DataIC50: 17nMAssay Description:Inhibition of VEGFR-2 (unknown origin) using poly-Glu-Ala-Tyr-biotin as substrate pre-incubated for 10 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650868(CHEMBL5633173)
Affinity DataIC50: 17nMAssay Description:Inhibition of VEGFR-1 (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(VANDETANIB | CHEBI:49960 | Vandetanib | GNF-PF-218...)
Affinity DataIC50: 30nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(VANDETANIB | CHEBI:49960 | Vandetanib | GNF-PF-218...)
Affinity DataIC50: 30nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(VANDETANIB | CHEBI:49960 | Vandetanib | GNF-PF-218...)
Affinity DataIC50: 30nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50399536(CHEMBL2180603)
Affinity DataIC50: 32nMAssay Description:Inhibition of human VEGFR-2 in presence of gamma-[33P]-ATP by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50637221(Fruquintinib | Hmpl-013 | HMPL-013 | HMPL013 | Fru...)
Affinity DataIC50: 35nMAssay Description:Inhibition of VEGFR-2 (unknown origin) by Kinase-Glo Max assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50637221(Fruquintinib | Hmpl-013 | HMPL-013 | HMPL013 | Fru...)
Affinity DataIC50: 35nMAssay Description:Inhibition of VEGFR-1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50637221(Fruquintinib | Hmpl-013 | HMPL-013 | HMPL013 | Fru...)
Affinity DataIC50: 35nMAssay Description:Inhibition of VEGFR-3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(VANDETANIB | CHEBI:49960 | Vandetanib | GNF-PF-218...)
Affinity DataIC50: 40nMAssay Description:Inhibition of VEGFR-2 (unknown origin) in presence of ATP at 2 uM by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 44nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50631721(CHEMBL5418423)
Affinity DataIC50: 51nMAssay Description:Inhibition of B-RAF V600E mutant (unknown origin) using magnesium acetate as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50649073(CHEMBL5619487)
Affinity DataIC50: 54nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50631721(CHEMBL5418423)
Affinity DataIC50: 57nMAssay Description:Inhibition of human recombinant B-Raf using magnesium acetate as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650870(CHEMBL5632998)
Affinity DataIC50: 60nMAssay Description:Inhibition of human VEGFR-2 incubated for 1 hr by ELISA analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50631721(CHEMBL5418423)
Affinity DataIC50: 73nMAssay Description:Inhibition of human recombinant EGFR using poly(Glu-Tyr) as substrate at 4:1 ratio in presence of ATP incubated for 60 mins by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650860(CHEMBL5633554)
Affinity DataIC50: 87nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650863(CHEMBL5632719)
Affinity DataIC50: 99nMAssay Description:Inhibition of EGFR (unknown origin) using TK as substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 100nMAssay Description:Inhibition of VEGFR-2 (unknown origin) in presence of ATP at 2 uM by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 1(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650860(CHEMBL5633554)
Affinity DataIC50: 110nMAssay Description:Inhibition of VEGFR-1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650862(CHEMBL5633828)
Affinity DataIC50: 120nMAssay Description:Inhibition of VEGFR-2 (unknown origin) in presence of ATP at 2 uM by enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650861(CHEMBL5631845)
Affinity DataIC50: 125nMAssay Description:Inhibition of VEGFR-3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650863(CHEMBL5632719)
Affinity DataIC50: 142nMAssay Description:Inhibition of human c-Kit using MEK1 as substrate incubated for 40 mins by gamma33P-ATP based scintillation counter analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650861(CHEMBL5631845)
Affinity DataIC50: 160nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650861(CHEMBL5631845)
Affinity DataIC50: 170nMAssay Description:Inhibition of VEGFR-1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650863(CHEMBL5632719)
Affinity DataIC50: 176nMAssay Description:Inhibition of FGFR1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650863(CHEMBL5632719)
Affinity DataIC50: 192nMAssay Description:Inhibition of human VEGFR-1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50631725(CHEMBL5430859)
Affinity DataIC50: 247nMAssay Description:Inhibition of VEGFR-2 (unknown origin) in presence of ATP at 2 uM by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650866(CHEMBL5631544)
Affinity DataIC50: 479nMAssay Description:Inhibition of EGFR (unknown origin) using TK as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(VANDETANIB | CHEBI:49960 | Vandetanib | GNF-PF-218...)
Affinity DataIC50: 500nMAssay Description:Inhibition of EGFR (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650863(CHEMBL5632719)
Affinity DataIC50: 500nMAssay Description:Inhibition of B-Raf (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650863(CHEMBL5632719)
Affinity DataIC50: 500nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50650859(CHEMBL5632016)
Affinity DataIC50: 640nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Tehran University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50631721(CHEMBL5418423)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant C-Raf using Glu-Tyr-Met-Pro-Met-Glu as substrate incubated for 60 mins by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
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