Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50022406
TargetSon of sevenless homolog 1(Human)
Tianjin University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50601067(CHEMBL5208088 | US11702418, Example 6-4)
Affinity DataKi:  0.330nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Tianjin University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50601067(CHEMBL5208088 | US11702418, Example 6-4)
Affinity DataKi:  0.430nMAssay Description:Binding affinity to human recombinant SOS1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Tianjin University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50601065(CHEMBL5206295 | US11702418, Example 4-4)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to human recombinant SOS1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Tianjin University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50601076(CHEMBL5209371 | US11702418, Example 6-12)
Affinity DataKi:  0.910nMAssay Description:Binding affinity to human recombinant SOS1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Tianjin University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50601084(CHEMBL5192659 | US11702418, Example 12-10)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to human recombinant SOS1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Tianjin University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50601091(CHEMBL5171096 | US11702418, Example 4-1)
Affinity DataKi:  2.60nMAssay Description:Binding affinity to human recombinant SOS1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Tianjin University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50581659(CHEMBL4519023 | US20230339952, Comparative Compoun...)
Affinity DataIC50: 3nMAssay Description:Inhibition of SOS1 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Tianjin University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50601064(CHEMBL5174300 | US11702418, Example 1-14)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to human recombinant SOS1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Tianjin University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50581659(CHEMBL4519023 | US20230339952, Comparative Compoun...)
Affinity DataIC50: 4nMAssay Description:Inhibition of SOS1/KRAS (unknown origin) protein-protein interaction by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Tianjin University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50607576(CHEMBL5218642)
Affinity DataIC50: 7nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Tianjin University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50601063(CHEMBL5202863 | US11702418, Example 1-13)
Affinity DataKi:  13nMAssay Description:Binding affinity to human recombinant SOS1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGTPase KRas(Human)
Tianjin University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50633192(CHEMBL5396975)
Affinity DataIC50: 340nMAssay Description:Inhibition of KRAS G12C mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGTPase KRas(Human)
Tianjin University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50633191(CHEMBL5436457)
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of KRAS G12C mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tianjin University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50601064(CHEMBL5174300 | US11702418, Example 1-14)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Tianjin University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50601063(CHEMBL5202863 | US11702418, Example 1-13)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGTPase KRas(Human)
Tianjin University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50607572(CHEMBL5220361)
Affinity DataKd: <1.00E+4nMAssay Description:Binding affinity to Cys12 residue of GDP bound human KRAS G12V mutant expressed in Escherichia coli BL21 Rosetta cells assessed as dissociation const...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGTPase KRas(Human)
Tianjin University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50607571(CHEMBL5219570)
Affinity DataKd: <1.00E+4nMAssay Description:Binding affinity to Cys12 residue of GDP bound human KRAS G12V mutant expressed in Escherichia coli BL21 Rosetta cells assessed as dissociation const...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGTPase KRas(Human)
Tianjin University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50607565(CHEMBL5219175)
Affinity DataKd:  1.50E+4nMAssay Description:Binding affinity to Cys12 residue of GDP bound human KRAS G12V mutant expressed in Escherichia coli BL21 Rosetta cells assessed as dissociation const...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed