Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50020839
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50280960(9-(3,4-Dimethoxy-phenyl)-8H-furo[3',4':6,7]naphtho...)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50633982(CHEBI:42053 | NEMORUBICIN)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM58490(SMR000466355 | (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM43839(Acid, 8)
Affinity DataIC50: 3nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of P-gp in human CEM cells incubated for 15 mins by calcein-AM efflux methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50305083(Ko143 | Ko-143 | 3-((3S,6S)-6-Isobutyl-9-methoxy-1...)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of ABCG2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataIC50: 10nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50633983(Aconitine | Aconitinum | NSC-56464 | NSC-759627 | ...)
Affinity DataIC50: 400nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50633981(CHEMBL5435203)
Affinity DataIC50: 510nMAssay Description:Inhibition of human ERalpha expressed in Saccharomyces cerevisiae co-expressing lacZ using CPRG as substrate incubated for 48 hrs by Colorimetric ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed