Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50020855
TargetHistone-lysine N-methyltransferase EZH2(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM31733(cid_4039540 | MLS-0092010.0001 | 3a,4,5,9b-tetrahy...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant full-length PRC2 catalytic core EZH2 Y641F mutant (unknown origin) using H3 (1-50) K27 Me1 biotin peptide as substrate incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM31723(MLS-0111569.0001 | cid_3112185 | 8-nitro-3a,4,5,9b...)
Affinity DataIC50: 0.870nMAssay Description:Inhibition of recombinant full-length PRC2 catalytic core EZH2 Y641F mutant (unknown origin) using H3 (1-50) K27 Me1 biotin peptide as substrate incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 7(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM31725(cid_3124342 | MLS-0111561.0001 | 3a,4,5,9b-tetrahy...)
Affinity DataIC50: 200nMAssay Description:Inhibition of HEPTP (unknown origin) using pNPP as substrate by high-throughput screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetM-phase inducer phosphatase 2(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50495825(CHEMBL3115916)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of full-length 6His/GST-tagged recombinant human CDC25B using OMFP as substrate incubated for 60 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetM-phase inducer phosphatase 2(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50634147(CHEMBL5407981)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of full-length 6His/GST-tagged recombinant human CDC25B using OMFP as substrate incubated for 60 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetM-phase inducer phosphatase 2(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM31733(cid_4039540 | MLS-0092010.0001 | 3a,4,5,9b-tetrahy...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of full-length 6His/GST-tagged recombinant human CDC25B using OMFP as substrate incubated for 60 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDiacylglycerol kinase alpha(Pig)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM48826(SMR000273171 | cid_3136298 | MLS000713690 | 8-etha...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of GST-fused pig DGK alpha expressed in Sf9 insect cells incubated for 2 hrs by HTS ADP-Glo DGK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM31733(cid_4039540 | MLS-0092010.0001 | 3a,4,5,9b-tetrahy...)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of human recombinant PTP1B using OMFP as substrate incubated for 60 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDual specificity protein phosphatase 1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM31756(cid_646406 | MLS-0007635.0001 | 6,7-dimethyl-3a,4,...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of 6His-tagged recombinant MKP1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using OMFP as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDual specificity protein phosphatase 1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM35407(SMR000019385 | cid_3243550 | 8-[(cyclohexyloxy)car...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of 6His-tagged recombinant MKP1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using OMFP as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDual specificity protein phosphatase 1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM31734(MLS-0025126.0001 | 8-ethoxycarbonyl-3a,4,5,9b-tetr...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of 6His-tagged recombinant MKP1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using OMFP as substrate incubated for 60 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSH3 and multiple ankyrin repeat domains protein 3(Mus musculus)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50634148(CHEMBL5410454)
Affinity DataKi:  1.00E+4nMAssay Description:Binding affinity to His-tagged murine Shank3 PDZ domain assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA adenine methylase(Escherichia coli K-12)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50634155(CHEMBL5397878)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of recombinant N-terminal 6-His tagged Escherichia coli DAM using ODN1 and ODN2 as substrate incubated for 20 mins in presence of S-adenos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA adenine methylase(Escherichia coli K-12)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50634153(CHEMBL5403950)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of recombinant N-terminal 6-His tagged Escherichia coli DAM using ODN1 and ODN2 as substrate incubated for 20 mins in presence of S-adenos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA adenine methylase(Escherichia coli K-12)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50634154(CHEMBL5402049)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of recombinant N-terminal 6-His tagged Escherichia coli DAM using ODN1 and ODN2 as substrate incubated for 20 mins in presence of S-adenos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA adenine methylase(Escherichia coli K-12)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50634151(CHEMBL5400357)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of recombinant N-terminal 6-His tagged Escherichia coli DAM using ODN1 and ODN2 as substrate incubated for 20 mins in presence of S-adenos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA adenine methylase(Escherichia coli K-12)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50634152(CHEMBL5430969)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of recombinant N-terminal 6-His tagged Escherichia coli DAM using ODN1 and ODN2 as substrate incubated for 20 mins in presence of S-adenos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetfMet-Leu-Phe receptor(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM42032(UNM000011066901 | cid_2873342 | 4-(4-chlorophenyl)...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human FPR expressed in human U-937 cells by fluorescence based ligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM40037(MLS000085196 | SMR000019736 | cid_1203912 | (3aS,4...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of GST-tagged recombinant PLK1 (unknown origin) using 5-carboxyfluorescein-KKRNRRLSVA-OH peptide as substrate incubated for 3 hrs in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSH3 and multiple ankyrin repeat domains protein 3(Mus musculus)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50634149(CHEMBL1738776)
Affinity DataKi:  1.70E+4nMAssay Description:Binding affinity to His-tagged murine Shank3 PDZ domain assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSH3 and multiple ankyrin repeat domains protein 3(Mus musculus)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50634150(CHEMBL5412233)
Affinity DataKi:  7.00E+4nMAssay Description:Binding affinity to His-tagged murine Shank3 PDZ domain assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetBifunctional protein GlmU(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM48826(SMR000273171 | cid_3136298 | MLS000713690 | 8-etha...)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis GlmU incubated for 30 mins by DTNB colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed