Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50021521
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataKi:  0.650nMAssay Description:Binding affinity to wild type GST-tagged EGFR (unknown origin) assessed as apparent inhibition constant in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50238177(CHEMBL4098072)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to EGFR L858R mutant (unknown origin) assessed as apparent inhibition constant in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50238177(CHEMBL4098072)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of wild type EGFR (unknown origin) preincubated for 5 mins followed by substrate and ATP addition and further incubated for 30 mins by HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50161957(CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity to EGFR L858R/T790M double mutant (unknown origin) assessed as apparent inhibition constant in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity to His-tagged recombinant EGFR L858R mutant (unknown origin) expressed in Baculovirus insect cells assessed as apparent inhibition c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity to EGFR L858R mutant (unknown origin) assessed as apparent inhibition constant in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50555575(Lazertinib | Yh25448 | C-18112003-G | GNS-1480 | G...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity to EGFR L858R mutant (unknown origin) assessed as apparent inhibition constant in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50161957(CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...)
Affinity DataKi:  6.90nMAssay Description:Binding affinity to wild type GST-tagged EGFR (unknown origin) assessed as apparent inhibition constant in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM4779(cid_156414 | PD0183805 | CHEMBL545315 | CHEMBL3196...)
Affinity DataKi:  7.10nMAssay Description:Binding affinity to EGFR L858R/T790M double mutant (unknown origin) assessed as apparent inhibition constant in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of wild type EGFR (unknown origin) preincubated for 5 mins followed by substrate and ATP addition and further incubated for 30 mins by HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataKi:  8nMAssay Description:Binding affinity to His-tagged recombinant EGFR L858R/T790M double mutant (unknown origin) expressed in Baculovirus insect cells assessed as apparent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM4779(cid_156414 | PD0183805 | CHEMBL545315 | CHEMBL3196...)
Affinity DataKi:  8.90nMAssay Description:Binding affinity to wild type GST-tagged EGFR (unknown origin) assessed as apparent inhibition constant in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataKi:  14nMAssay Description:Binding affinity to His-tagged recombinant EGFR (unknown origin) expressed in Baculovirus insect cells assessed as apparent inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50555575(Lazertinib | Yh25448 | C-18112003-G | GNS-1480 | G...)
Affinity DataKi:  34nMAssay Description:Binding affinity to EGFR L858R/T790M double mutant (unknown origin) assessed as apparent inhibition constant in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataKi:  45nMAssay Description:Binding affinity to EGFR L858R/T790M double mutant (unknown origin) assessed as apparent inhibition constant in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50238177(CHEMBL4098072)
Affinity DataKi:  99nMAssay Description:Binding affinity to wild type GST-tagged EGFR (unknown origin) assessed as apparent inhibition constant in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50238177(CHEMBL4098072)
Affinity DataKi:  224nMAssay Description:Binding affinity to EGFR L858R/T790M double mutant (unknown origin) assessed as apparent inhibition constant in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataKi:  256nMAssay Description:Binding affinity to EGFR L858R/T790M double mutant (unknown origin) assessed as apparent inhibition constant in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50555575(Lazertinib | Yh25448 | C-18112003-G | GNS-1480 | G...)
Affinity DataKi:  271nMAssay Description:Binding affinity to wild type GST-tagged EGFR (unknown origin) assessed as apparent inhibition constant in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataKi:  434nMAssay Description:Binding affinity to wild type GST-tagged EGFR (unknown origin) assessed as apparent inhibition constant in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed