Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50020774
TargetHeat shock protein HSP 90-alpha(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50394053(CHEMBL2158562)
Affinity DataKi: <1nMAssay Description:Inhibition of N-terminal human Hsp90-alpha ATP binding domain (2 to 236 residues) overexpressed in HEK293T cell lysate by fluorescence polarization a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50394053(CHEMBL2158562)
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminal human Hsp90-alpha ATP binding domain (2 to 236 residues) overexpressed in HEK293T cell lysate by fluorescence polarization a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50633502(CHEMBL5406955)
Affinity DataIC50: 9nMAssay Description:Inhibition of N-terminal human Hsp90-alpha ATP binding domain (2 to 236 residues) overexpressed in HEK293T cell lysate by fluorescence polarization a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM20926(5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-...)
Affinity DataKi:  9nMAssay Description:Displacement of 2-[4-(2-Chloro-5-hydroxy-4-methoxy-phenyl)-5-cyano-7Hpyrrolo[2,3-d]pyrimidin-2-ylsulfanyl]-N-(2,2,2-trifluoroethyl)-acetamide spy lig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM20926(5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-...)
Affinity DataIC50: 21nMAssay Description:Inhibition of N-terminal human Hsp90-alpha ATP binding domain (2 to 236 residues) overexpressed in HEK293T cell lysate by fluorescence polarization a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM33234(thieno[2,3-d]pyrimidine, 34a)
Affinity DataKi:  42nMAssay Description:Displacement of 2-[4-(2-Chloro-5-hydroxy-4-methoxy-phenyl)-5-cyano-7Hpyrrolo[2,3-d]pyrimidin-2-ylsulfanyl]-N-(2,2,2-trifluoroethyl)-acetamide spy lig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM33236(thieno[2,3-d]pyrimidine, 34c)
Affinity DataIC50: 47nMAssay Description:Inhibition of N-terminal human Hsp90-alpha ATP binding domain (2 to 236 residues) overexpressed in HEK293T cell lysate by fluorescence polarization a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50633503(CHEMBL5420862)
Affinity DataIC50: 53nMAssay Description:Inhibition of N-terminal human Hsp90-alpha ATP binding domain (2 to 236 residues) overexpressed in HEK293T cell lysate by fluorescence polarization a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM33234(thieno[2,3-d]pyrimidine, 34a)
Affinity DataIC50: 56nMAssay Description:Inhibition of N-terminal human Hsp90-alpha ATP binding domain (2 to 236 residues) overexpressed in HEK293T cell lysate by fluorescence polarization a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50633501(CHEMBL5412215)
Affinity DataIC50: 282nMAssay Description:Inhibition of N-terminal human Hsp90-alpha ATP binding domain (2 to 236 residues) overexpressed in HEK293T cell lysate by fluorescence polarization a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed