Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50021636
TargetSerine/threonine-protein kinase B-raf(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM50642917(CHEMBL5565399)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal GST fused wild type human BRAF (433 to 726 residues) expressed in Sf21 insect cells using MEK1 as substrate incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM514652((S)-N-(3-(2-(((R)-1-hydroxypropan-2- yl)amino)-6-m...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of CRAF (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM50642920(CHEMBL5542253)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of N-terminal GST fused wild type human BRAF (433 to 726 residues) expressed in Sf21 insect cells using MEK1 as substrate incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM50642921(CHEMBL5570335)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of N-terminal GST fused wild type human BRAF (433 to 726 residues) expressed in Sf21 insect cells using MEK1 as substrate incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM514652((S)-N-(3-(2-(((R)-1-hydroxypropan-2- yl)amino)-6-m...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of ARAF (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM514652((S)-N-(3-(2-(((R)-1-hydroxypropan-2- yl)amino)-6-m...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of N-terminal GST fused wild type human BRAF (433 to 726 residues) expressed in Sf21 insect cells using MEK1 as substrate incubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM50642919(CHEMBL5572210)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of N-terminal GST fused wild type human BRAF (433 to 726 residues) expressed in Sf21 insect cells using MEK1 as substrate incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM50642924(CHEMBL5572440)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal GST fused wild type human BRAF (433 to 726 residues) expressed in Sf21 insect cells using MEK1 as substrate incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM50642923(CHEMBL5575362)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of N-terminal GST fused wild type human BRAF (433 to 726 residues) expressed in Sf21 insect cells using MEK1 as substrate incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM50642922(CHEMBL5594839)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of N-terminal GST fused wild type human BRAF (433 to 726 residues) expressed in Sf21 insect cells using MEK1 as substrate incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM50642925(CHEMBL5590216)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of N-terminal GST fused wild type human BRAF (433 to 726 residues) expressed in Sf21 insect cells using MEK1 as substrate incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM50642918(CHEMBL5563313)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of N-terminal GST fused wild type human BRAF (433 to 726 residues) expressed in Sf21 insect cells using MEK1 as substrate incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM514652((S)-N-(3-(2-(((R)-1-hydroxypropan-2- yl)amino)-6-m...)
Affinity DataIC50: 107nMAssay Description:Inhibition of wild type DDR1 (unknown origin) at in presence of ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed