Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) with all data for entry = 50022380
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM10849(CHEMBL113 | 1,3,7-trimethyl-3,7-dihydropurine-2,6-...)
Affinity DataKd:  690nMAssay Description:Binding affinity to human SIRT3 assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50553871(CHEMBL1392132)
Affinity DataKd:  3.90E+3nMAssay Description:Binding affinity to human SIRT3 (102 to 399 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50553871(CHEMBL1392132)
Affinity DataIC50: 7.58E+4nMAssay Description:Activation of human SIRT3 (unknown origin) deacetylation activity using fluorogenic substrate measured upto 120 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed