Compile Data Set for Download or QSAR
Report error Found 44 Enz. Inhib. hit(s) with all data for entry = 50021158
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637582(CHEMBL5555976)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of human ENPP1 using TMP-pNP as substrate at pH 9.5 preincubated for 30 mins followed by substrate addition and measured after 60 mins by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM729565(US20250101019, Example 78)
Affinity DataIC50: 1nMAssay Description:Inhibition of ENNP1 (unknown origin) using 2',3'-cGAMP as substrate preincubated with compound followed by substrate addition and measured after 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM706145(US20240383893, Compound 2)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of ECD-his tagged human ENPP1 using 2',3'-cGAMP as substrate preincubated for 15 mins followed by substrate addition and measured after 60...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM722840(US20250059218, Compound 45)
Affinity DataKi: <2nMAssay Description:Inhibition of ENPP1 (unknown origin) using cGAMP as substrate assessed as inhibition constant at pH 7.4More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM608806(US11701371, Compound 76 | US11707471, Compound 76 ...)
Affinity DataKi: <2nMAssay Description:Inhibition of ENPP1 (unknown origin) using cGAMP as substrate assessed as inhibition constant at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637582(CHEMBL5555976)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human ENPP1 using AMP-pNP as substrate at pH 9.5 preincubated for 30 mins followed by substrate addition and measured after 60 mins by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM608806(US11701371, Compound 76 | US11707471, Compound 76 ...)
Affinity DataKi:  4nMAssay Description:Inhibition of ENPP1 in mouse plasma using [32P]cGAMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637586(CHEMBL5559810)
Affinity DataIC50: 10nMAssay Description:Inhibition of ENPP1 (unknown origin) using TMP-pNP as substrate preincubated for 10 mins followed by substrate addition and measured immediately unde...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637577(CHEMBL5560016)
Affinity DataKi: <10nMAssay Description:Inhibition of ENPP1 (unknown origin) using cGAMP as substrate assessed as inhibition constant at pH 7.4More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637577(CHEMBL5560016)
Affinity DataIC50: 10nMAssay Description:Inhibition of ENPP1 in HEK293 cells using 2',3'-cGAMP as substrate by AMP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50179357(CHEMBL1783609)
Affinity DataKi:  11nMAssay Description:Inhibition of ENPP1 (unknown origin) using cGAMP as substrate assessed as inhibition constant at pH 9More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637579(CHEMBL5555042)
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human ENPP1 using 2',3'-cGAMP as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM608782(US11701371, Compound 1 | US11707471, Compound 1 | ...)
Affinity DataKi:  33nMAssay Description:Inhibition of ENPP1 (unknown origin) using cGAMP as substrate assessed as inhibition constant at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637590(CHEMBL5556593)
Affinity DataKi:  38nMAssay Description:Inhibition of ENPP1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637591(CHEMBL5560451)
Affinity DataKi:  41nMAssay Description:Inhibition of ENPP1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM448056(US10689376, Compound 78 | US11142524, Compound 78)
Affinity DataIC50: 79nMAssay Description:Inhibition of recombinant human ENPP-1 using p-Nph5'-TMP as substrate incubated for 45 mins by absorbance based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM448030(US10689376, Compound 21 | US11142524, Compound 21)
Affinity DataIC50: 86nMAssay Description:Inhibition of recombinant human ENPP-1 using p-Nph5'-TMP as substrate incubated for 45 mins by absorbance based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637583(CHEMBL5567352)
Affinity DataIC50: 87nMAssay Description:Inhibition of ENPP1 (unknown origin) using 2',3'-cGAMP as substrate preincubated for 1 hrs followed by substrate addition and measured after 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637585(CHEMBL5556388)
Affinity DataIC50: 91nMAssay Description:Inhibition of ENPP1 (unknown origin) using 2',3'-cGAMP as substrate preincubated for 1 hrs followed by substrate addition and measured after 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637581(CHEMBL5556989)
Affinity DataIC50: 100nMAssay Description:Inhibition of human ENPP-1 using 2',3'-cGAMP as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by AMP-G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637581(CHEMBL5556989)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human ENPP-1 using AMP-pNP as substrate incubated for 20 mins by absorbance based plate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637588(CHEMBL5558774)
Affinity DataKi: <100nMAssay Description:Inhibition of ENPP1 (unknown origin) using TMP-pNP as substrate preincubated for 10 mins followed by substrate addition and measured immediately unde...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637587(CHEMBL5542915)
Affinity DataKi: <100nMAssay Description:Inhibition of ENPP1 (unknown origin) using TMP-pNP as substrate preincubated for 10 mins followed by substrate addition and measured immediately unde...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM448056(US10689376, Compound 78 | US11142524, Compound 78)
Affinity DataIC50: 116nMAssay Description:Inhibition of recombinant human ENPP-1 using ATP as substrate incubated for 20 mins by Cell titer Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM648605(US20240034727, Compound I-35 | 2-((2-((3-chloro-4-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant human ENPP1 using p-NP-TMP as substrate incubated for 45 mins by absorbance based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM648600(US20240034727, Compound I-30 | 2,3-dihydroxypropyl...)
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant human ENPP1 using p-NP-TMP as substrate incubated for 45 mins by absorbance based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM648531(US20240034727, Compound I-1 | 2-((2-((3,4- dimetho...)
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant human ENPP1 using p-NP-TMP as substrate incubated for 45 mins by absorbance based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM448056(US10689376, Compound 78 | US11142524, Compound 78)
Affinity DataIC50: 271nMAssay Description:Inhibition of recombinant human ENPP-1 using TMP as substrate incubated for 45 mins by absorbance based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637582(CHEMBL5555976)
Affinity DataIC50: 400nMAssay Description:Inhibition of ENPP1 (unknown origin) expressed in human MDA-MB-231 cells using TMP-pNP as substrate preincubated for 60 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637584(CHEMBL5555975)
Affinity DataIC50: 647nMAssay Description:Inhibition of ENPP1 (unknown origin) using 2',3'-cGAMP as substrate preincubated for 1 hrs followed by substrate addition and measured after 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637592(CHEMBL5527991)
Affinity DataIC50: 732nMAssay Description:Inhibition of ENPP1 in human MDA-MB-231 cells using pNP-TMP as substrate incubated for 4 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637580(CHEMBL5562268)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human ENPP1 using 2',3'-cGAMP as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM633440(N-(4-(6,7-dimethoxy-4-oxo-3,4-dihydrophthalazin-1-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human ENPP1 using 2',3'-cGAMP as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637578(CHEMBL5532526)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human ENPP1 using 2',3'-cGAMP as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50179357(CHEMBL1783609)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of ENPP1 (unknown origin) using cGAMP as substrate assessed as inhibition constant at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637589(CHEMBL5567605)
Affinity DataKi:  3.87E+3nMAssay Description:Inhibition of ENPP1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50118232(ATP, 2-meS | CHEMBL336208 | 2-MeSATP)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of recombinant human ENPP1 using ATP as substrate assessed as inhibition constant incubated for 30 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of recombinant human ENPP1 using ATP as substrate assessed as inhibition constant incubated for 30 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50118221(alpha,beta-meATP | DIPHOSPHOMETHYLPHOSPHONIC ACID ...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of recombinant human ENPP1 using ATP as substrate assessed as inhibition constant incubated for 30 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM18136(alpha, beta-methyleneadenosine 5 -diphosphate | ci...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of recombinant human ENPP1 using ATP as substrate assessed as inhibition constant incubated for 30 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM86488(NSC_0 | CAS_81790-82-1 | ATP, Bz)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of recombinant human ENPP1 using ATP as substrate assessed as inhibition constant incubated for 30 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50637576(CHEMBL4285222)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of recombinant human ENPP1 using ATP as substrate assessed as inhibition constant incubated for 30 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50597649(CHEMBL4277262)
Affinity DataKi:  5.14E+3nMAssay Description:Inhibition of recombinant human ENPP1 using ATP as substrate assessed as inhibition constant incubated for 30 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50179358(CHEMBL1206141)
Affinity DataKi:  1.20E+4nMAssay Description:Competitive inhibition of human ENPP1 transfected in HEK293T cells using pnp-TMP as substrate preincubated for 3 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed