Compile Data Set for Download or QSAR
Report error Found 72 Enz. Inhib. hit(s) with all data for entry = 50020600
TargetALK tyrosine kinase receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataKi: <0.0700nMAssay Description:Binding affinity to ALK (unknown origin) assessed as inhibition of constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631771(CHEMBL5438242)
Affinity DataKi: <0.100nMAssay Description:Binding affinity to ALK (unknown origin) assessed as inhibition of constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50018815(CHEMBL3286820)
Affinity DataKi: <0.200nMAssay Description:Binding affinity to ALK (unknown origin) assessed as inhibition of constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631772(CHEMBL5400169)
Affinity DataIC50: 0.211nMAssay Description:Inhibition of His-tagged human recombinant wild type TRKCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50018815(CHEMBL3286820)
Affinity DataKi:  0.290nMAssay Description:Binding affinity to ALK L1196M mutant (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631772(CHEMBL5400169)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of N-terminal His-tagged human recombinant wild type TRKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631772(CHEMBL5400169)
Affinity DataIC50: 0.533nMAssay Description:Inhibition of His-tagged human recombinant wild type TRKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of His-tagged human recombinant wild type TRKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631771(CHEMBL5438242)
Affinity DataKi:  0.620nMAssay Description:Binding affinity to ALK L1196M mutant (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to ALK L1196M mutant (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataKi:  0.740nMAssay Description:Binding affinity to ALK (unknown origin) assessed as inhibition of constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50018822(CHEMBL3286812)
Affinity DataKi:  0.850nMAssay Description:Binding affinity to ALK (unknown origin) assessed as inhibition of constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of His-tagged human recombinant wild type TRKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged human recombinant TRKA G595R mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of His-tagged human recombinant TRKC G623R mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of His-tagged human recombinant wild type TRKCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631772(CHEMBL5400169)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of His-tagged human recombinant TRKA G595R mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of His-tagged human recombinant wild type TRKCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50018819(CHEMBL3286809)
Affinity DataKi:  2.80nMAssay Description:Binding affinity to ALK (unknown origin) assessed as inhibition of constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631772(CHEMBL5400169)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant TRKA G595R mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50018816(CHEMBL3286808)
Affinity DataKi:  4nMAssay Description:Binding affinity to ALK (unknown origin) assessed as inhibition of constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631772(CHEMBL5400169)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of His-tagged human recombinant TRKC G623R mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631767(CHEMBL5439075)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataKi:  8.20nMAssay Description:Binding affinity to ALK L1196M mutant (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50018822(CHEMBL3286812)
Affinity DataKi:  8.20nMAssay Description:Binding affinity to ALK L1196M mutant (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of His-tagged human recombinant TRKA G667C mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50363196(CHEMBL1944698)
Affinity DataIC50: 13nMAssay Description:Inhibition of CDK2 (unknown origin) by LANCE ULight TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631767(CHEMBL5439075)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant FLT3 in human MV4-11 cells assessed as reduction in ERK phosphorylation by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631768(CHEMBL5429085)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant FLT3 in human MV4-11 cells assessed as reduction in ERK phosphorylation by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631770(CHEMBL5419439)
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant FLT3 in human MV4-11 cells assessed as reduction in ERK phosphorylation by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50018819(CHEMBL3286809)
Affinity DataKi:  35nMAssay Description:Binding affinity to ALK L1196M mutant (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50018816(CHEMBL3286808)
Affinity DataKi:  38nMAssay Description:Binding affinity to ALK L1196M mutant (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 46nMAssay Description:Inhibition of human JAK2 by western blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 46nMAssay Description:Inhibition of His-tagged human recombinant TRKA G667C mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 48nMAssay Description:Inhibition of His-tagged human recombinant TRKC G623R mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant TYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50363196(CHEMBL1944698)
Affinity DataIC50: 56nMAssay Description:Inhibition of FLT3 in human MV4-11 cells assessed as FLT3 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631767(CHEMBL5439075)
Affinity DataIC50: 57nMAssay Description:Inhibition of human recombinant TYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50384879(CHEMBL2035185)
Affinity DataIC50: 60nMAssay Description:Inhibition of FLT3 in human MV4-11 cells assessed as FLT3 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631772(CHEMBL5400169)
Affinity DataIC50: 64nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 69nMAssay Description:Inhibition of His-tagged human recombinant TRKA G595R mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50623116(CHEMBL5416999)
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant JAK2More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631769(CHEMBL5434272)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant FLT3 in human MV4-11 cells assessed as reduction in ERK phosphorylation by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631770(CHEMBL5419439)
Affinity DataIC50: 71nMAssay Description:Inhibition of human recombinant TYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50363196(CHEMBL1944698)
Affinity DataIC50: 73nMAssay Description:Inhibition of human JAK2 by western blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631770(CHEMBL5419439)
Affinity DataIC50: 77nMAssay Description:Inhibition of human recombinant JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631769(CHEMBL5434272)
Affinity DataIC50: 84nMAssay Description:Inhibition of human recombinant JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Arkansas

Curated by ChEMBL
LigandPNGBDBM50631770(CHEMBL5419439)
Affinity DataIC50: 88nMAssay Description:Inhibition of human recombinant CDK2 by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
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