Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50020979
LigandPNGBDBM418555(8-(1,3-Dimethylpyrazol-4- yl)-1-[3-fluoro-5-(tride...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of ATM (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50565800(Azd-1390 | Azd1390 | US20240294545, Compound AZD13...)
Affinity DataIC50: 0.780nMAssay Description:Inhibition of ATM (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetWee1-like protein kinase(Human)TBA
LigandPNGBDBM50635712(CHEMBL5555318)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of WEE1 (unknown origin) by discoverX kinome scan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50635714(CHEMBL5558159 | US20250268873, Compound 569)
Affinity DataIC50: 0.890nMAssay Description:Inhibition of DNA-PK in human HCT-116 cells measured after 1 hr by Bradford assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM315715(US10172859, Example 136 | (S)-[2-Chloro-4- fluoro-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of DNA-PK in human HCT-116 cells measured after 1 hr by Bradford assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM324932(2-(2-isopropylphenyl)-9-(4- | US10189841, Compound...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human recombinant USP1 expressed in baculovirus expressed in Bac-to-Bac baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50635713(Azd-9574 | AZD9574)
Affinity DataIC50: 5nMAssay Description:Inhibition of PARP1 (unknown origin) expressed in Escherichia coli BL21 incubated for 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM580031(US11485736, Compound Table 3.15)
Affinity DataIC50: 11nMAssay Description:Inhibition of USP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM371049(US10239843, Example 156)
Affinity DataEC50:  19nMAssay Description:Agonist activity at PARG (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM205479(PDD00017273 (4) | US20230278998, Compound PDD00017...)
Affinity DataEC50:  26nMAssay Description:Agonist activity at PARG (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50069762(CHEMBL3182437 | ML323 | US9802904, 87)
Affinity DataIC50: 76nMAssay Description:Inhibition of human recombinant USP1 expressed in Escherichia coli BL21 (DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50635709(CHEMBL5527941)
Affinity DataKd:  355nMAssay Description:Binding affinity to RAD51 (unknown origin) assessed as dissociation constant by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50635709(CHEMBL5527941)
Affinity DataKi:  366nMAssay Description:Binding affinity to RAD51 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50635711(CHEMBL5559362)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of RAD52 (unknown origin) by FRET analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50635710(CHEMBL5542154)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of RAD52 (unknown origin) by FRET analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM370895(US10239843, Example 2)
Affinity DataEC50:  3.90E+3nMAssay Description:Agonist activity at PARG (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDNA polymerase theta(Human)TBA
LigandPNGBDBM50226181(Carbamic acid 5-hydroxy-6-{4-hydroxy-3-[4-hydroxy-...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of human DNA polymerase theta (1 to 987 residues) expressed in Sf9 insect cells incubated for 40 mins by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50565809(CHEMBL1718911)
Affinity DataKd:  2.58E+4nMAssay Description:Binding affinity to RAD52 (unknown origin) assessed as dissociation constant by Surface Plasmon ResonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed